The Pros And Cons Of Januvia And Janumet
Januvia doesnt usually cause weight loss or gain.Januvia is a type 2 diabetes drug that was approved in 2006. It is also available in a combination pill that contains the drug metformin. They are the first drugs in a new class called the selective dipeptidyl peptidase-4 inhibitors, or DPP-4 inhibitors. Januvia has a big advantage in that it can stimulate insulin production in the body, and may be less likely to cause hypoglycemia than other drugs. If blood glucose falls too low, the drug ceases to stimulate insulin production. The disadvantage? The price. The drug is “very expensive,” says Glenn Cunningham, MD, an endocrinologist and professor at Baylor College of Medicine in Houston. He notes that it costs $160 for a 30-day supply of 100-mg tablets. Nevertheless, “Januvia is becoming a much more popular drug,” Dr. Cunningham says. It does not cause weight gain or weight loss, he explained, and is less likely to cause hypoglycemia.Continue reading > >
How Should This Medicine Be Used
Sitagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take sitagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sitagliptin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Sitagliptin helps to control high blood sugar but does not cure diabetes. Continue to take sitagliptin even if you feel well. Do not stop taking sitagliptin without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
The Effectiveness Of Combination Treatment With Insulin And Sitagliptin In T2 Patients
Patients on therapy may see increased reduction in HbA1c, lower BP, lower lipid values.
Dipeptidyl peptidase-4 inhibitors are used for the treatment of type 2 diabetes. Sitagliptin was the first medication approved for people with type 2 diabetes who are taking insulin. There are not a lot of studies that have investigated the use of DPP-4 and insulin therapy in patients with long-term diabetes diagnosis. Currently, there arent any studies that have evaluated the efficiency of DPP-4 inhibitors in activating insulin feedback in patients with minimal insulin secretion who are on insulin therapy.
Researchers evaluated the effectiveness and safety of insulin-sitagliptin combination treatment to establish the benefit of this regimen in patients with type 2 diabetes. The study design was a multicenter retrospective study from November 2011 to March 2013. The study was conducted in 36 diabetes clinic in Kanagawa Prefecture, Japan. Patients who were eligible were on insulin 6 months prior and on sitagliptin if their HbA1c was 7.0% or higher with insulin therapy. The primary endpoint was the variation in HbA1c levels. The results from this study were reported as mean + standard deviation. Other endpoints in this study were weight, blood pressure values, total cholesterol, and triglycerides.
The researchers concluded that sitagliptin and insulin combination therapy decreased HbA1c in a real-world setting.
Practice Pearls:
Read Also: What Happens When You Take Insulin
Type 2 Diabetes Mellitus
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
100 mg PO qDay
- eGFR 45 to < 90 mL/min/1.73 m2: No dosage adjustment necessary
- eGFR 30 to < 45 mL/min/1.73 m2: 50 mg PO qDay
- eGFR < 30 mL/min/1.73 m2: 25 mg PO qDay
- End-stage renal disease requiring hemodialysis or peritoneal dialysis: 25 mg PO qDay regardless of timing of dialysis
Hepatic impairment
- Mild to moderate impairment: Dose adjustment not necessary
- Severe impairment: Not studied
Limitations of use
- Should not be used in patients with type 1 diabetes
- Not studied in patients with a history of pancreatitis unknown whether these patients are at increased risk for development of pancreatitis while using sitagliptin
Safety and efficacy not established
Three double-blind, placebo-controlled studies evaluated the efficacy and safety of sitagliptin in patients aged 10-17 years with uncontrolled T2DM, with or without insulin therapy results showed effects of patients treated with sitagliptin were not significantly different from placebo
Serious – Use Alternative
Monitor Closely
Minor
What Is Januvia Used For
If you have type 2 diabetes, your doctor might prescribe Januvia. Its used together with diet and exercise to help manage blood sugar levels in adults with this condition.
With type 2 diabetes, your blood sugar levels are too high. This is because the insulin that your body naturally releases doesnt work as well as usual.
Januvia blocks a certain protein in your body that inactivates incretin hormones. These hormones help control your blood sugar levels by affecting your pancreas and stimulating it to make and release insulin. By blocking the protein, more active incretin hormones are available to help control your blood sugar levels.
Note: Januvias indication doesnt include type 1 diabetes. In fact, this is a limitation of the drug, which means it cannot be used for the condition. Additionally, Januvia isnt used to treat diabetes in people who have had pancreatitis . Its not known if Januvia is safe in people who have had pancreatitis. This is another limitation to Januvias uses.
Find answers below to some commonly asked questions about Januvia.
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What To Ask Your Doctor
If you have type 2 diabetes, your doctor might prescribe Januvia.
If you have questions about taking this drug, talk with your doctor or pharmacist. They can tell you about other treatments you can use for your condition.
Heres an article about diabetes treatments you might find helpful. And here are some questions you can ask your doctor about Januvia:
- Can I take Januvia with natural diabetes remedies, such as apple cider vinegar?
- How often do I need to check my blood sugar levels when taking Januvia?
- Is Januvia better than other drugs, such as saxagliptin , linagliptin , and alogliptin ?
- Can I reduce the number of pills I take for diabetes by switching to Janumet?
- Does Januvia interact with birth control, such as birth control pills?
- Will Januvia make me constipated?
You can learn more about diabetes, which Januvia is used for, by subscribing to Healthlines type 2 diabetes newsletter.
What Are The Side Effects With Januvia
All drugs have side effects and come with some level of risk. However, the risk from untreated type 2 diabetes can also adversely impact your health. Left untreated, type 2 diabetes can cause serious medical problems such as nerve and kidney damage, vision problems, and heart disease.
In general, Januvia is well-tolerated. In studies, the overall incidence of side effects, low blood sugar, and discontinuation of Januvia due to side effects were similar to placebo .
Before you start Januvia, tell your doctor if you have a history of pancreatitis, heart failure or heart disease, or kidney disease. Also, tell your doctor if you are pregnant or planning on having a baby.
If you have any concerns about the following side effects, speak with your doctor.
Serious side effects with Januvia may include:
- low blood sugar, especially when used with other medications for diabetes such as insulin or sulfonylureas
- pancreatitis
- serious allergic reactions
- kidney problems that may lead to dialysis.
- severe joint pain
- serious skin reaction called a bullous pemphigoid with DPP-4 inhibitors. Call your doctor immediately if you develop blisters or the breakdown of the outer layer of your skin . You may need to stop taking Januvia.
Common side effects with Januvia :
- upper respiratory infection
Also Check: When Is Insulin Needed For Type 2 Diabetes
Who Can And Can’t Take Sitagliptin
Sitagliptin can be taken by adults .
Sitagliptin is not suitable for some people. To make sure it’s safe for you, tell your doctor if you:
- have had an allergic reaction to sitagliptin or any other medicines in the past
- have problems with your pancreas
- have gallstones or very high levels of triglycerides in your blood
- are a heavy drinker or dependent on alcohol
- have any problems with your kidneys
- are pregnant or breastfeeding, or trying to get pregnant
This medicine is not used to treat type 1 diabetes .
Compare Januvia Vs Human Insulin
Oral blood sugar-lowering medicine. Januvia is not linked to worsening heart failure like other medicines in its class. It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines. Some types of this medication are available without a prescription. Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose. Available in different combinations so that you can do one shot or multiple shots a day. 143 reviews so far Have you used Januvia ? Leave a review 57 reviews so far Have you used Humulin ? Leave a review The Humulin FDA package insert doesnât have numbers about how common side effects are. History of pancreatitis High blood triglyceride levels Gallstones History of alchoholism Kidney problemsContinue reading > >
Also Check: Normal A1c Range For Diabetics
How Can I Stay Healthy While Taking Januvia
While Januvia does have the potential for serious side effects such as allergic reactions or pancreatitis, the most common side effects may be milder. Those tend to include upper respiratory infection, runny nose, or headache.
Try to follow your healthcare providerâs dietary instructions and continue regular physical activity, as well as blood glucose monitoring and A1C testing.
It is important to inform your healthcare provider of all of your other health conditions and any prescription medications, OTC medications, vitamins, supplements, or herbs you are taking. This way, your provider can make the best decision about what medication and dose work best for you.
Speak with your healthcare provider to learn more about if Januvia is the right medication for you.
Tell Your Doctor About All Your Medical Conditions And Medications
Because of the risk of side effects, you should tell your doctor about all your physical conditions you have as well as all prescription and over-the-counter medications, supplements, and herbal remedies you take. They may not seem important, but this information could make treatment with Januvia safer.
Make sure you tell your doctor about any of the following physical conditions you might have:
- Kidney problems
- Diabetic ketoacidosis
- Any allergic reaction to Januvia
Before prescribing Januvia, the doctor will need to know if the patient is pregnant, nursing, or planning on becoming pregnant or breastfeeding a baby.
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Metformin Glipizide Januvia And Actos Related Questions
Metformin, Glipizide, Januvia, and Actos Related Questions Metformin, Glipizide, Januvia, and Actos Related Questions A friend’s father is taking all of those drugs, and I wonder if that’s a dangerous mix. I read about them today, and it seems Actos is the worst, followed by Glipizide. I also read in an older thread here that it’s dangerous to take Actos and Januvia together. Why is that? Is that an unwelcome combination only for causing weight gain? He thinks one of these drugs is raising his cholesterol levels, but I didn’t find it mentioned among the side-effects of any of them. I think only Actos could be a potential suspect, although some studies show it may lower cholesterol. What do you think? He is mildly anemic with no apparent reason. I’ve seen it mentioned many times here that Metformin depletes vitamin B12, but his B12 is within the lab ranges. I don’t really trust many of those ranges, so I think he could still be B12 deficient with a result of 432 . Need to ask if he is supplementing with B12.Continue reading > >
Sitagliptin For The Treatment Of Patients With Type 2 Diabetes
HEATHER P. WHITLEY, PharmD, BCPS, CDE, Auburn University Harrison School of Pharmacy and the University of Alabama School of Medicine, Tuscaloosa, Alabama
Am Fam Physician. 2007 Sep 15 76:861-862.
Sitagliptin is an incretin enhancer and the first medication from the gliptin class to be marketed. Incretin hormones are released from intestinal cells in response to carbohydrate- or fat-rich meals and stimulate pancreatic beta cells to release insulin, which stops hepatic glucose production. Sitagliptin prolongs the action of incretin hormones by prohibiting their degradation through inhibition of the dipeptidyl peptidase-4 enzyme. Sitagliptin is labeled as adjunct therapy to diet and exercise, metformin , or thiazolidinediones in adults with type 2 diabetes.
|
100 mg daily less in patients with renal insufficiency |
25-, 50-, and 100-mg tablets |
$175 |
*Average wholesale cost, based on Red Book, Montvale, N.J.: Medical Economics Data, 2007.
| Name | ||
|---|---|---|
|
100 mg daily less in patients with renal insufficiency |
25-, 50-, and 100-mg tablets |
$175 |
*Average wholesale cost, based on Red Book, Montvale, N.J.: Medical Economics Data, 2007.
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Are There Any Natural Alternatives I Can Use Instead Of Januvia To Help Control My Blood Sugar
Natural alternatives shouldnt replace any diabetes medication that your doctor has prescribed for you. But researchers are studying how certain foods and supplements can increase or decrease the amount of sugar in your body.
Clinical studies looked at the effect of cinnamon on people with type 2 diabetes. These people took between 0.5 g and 6 g of cinnamon each day for 40 days to four months. In some studies, cinnamon was effective at improving blood sugar levels. In other studies, there was no benefit.
More studies are needed to confirm whether its effective and safe for people to take cinnamon for type 2 diabetes.
Another natural alternative thats been researched is the mineral chromium. It may help reduce blood sugar levels. But according to a review of clinical studies, its not clear whether chromium is effective and safe for treating type 2 diabetes. More studies are needed.
If youre interested in taking cinnamon, chromium, or another natural alternative to help treat type 2 diabetes, talk with your doctor. They can discuss the pros and cons with you.
Can Januvia And Glipizide Be Taken Together Safely
Community Answers No, The two drugs are virtually identical. If both of the drugs are taken together may potentiate the risk of hypoglycemia. Yes Januvia can be taken with any other medication for Type 2 diabetes. There are studies in the prescribing information of januvia used in combination with glipizide, metformin, insulin. There are no contraindications to take the two products together, however, it is recommended to closely monitor patients hypoglycemia when januvia is used together with any sulfolyurea like glipizide. I take glipizide, metformin at their max dose and januvia . My diabetes is still out of control. my weight does not change. I eat no refined sugars. In the last 18 months my digestion has changed so dramatically that I can eat nothing but bland foods . Know more here READ THESE NEXT: Can a new diabetes drug also help my mother lose weight? Essential Info About Type 2 Diabetes Drugs When Blood Sugar HighContinue reading > >
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Can You Take Januvia And Insulin Together
4/5you take JANUVIAcaninsulininsulinyouseen here
, the brand name for sitaglipti, is a DPP-IV inhibitor which is used to lower the blood glucose levels of people with type 2 diabetes. It can be taken alongside other medication, such as insulin.
Beside above, what time of day should you take Januvia? You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take sitagliptin before or after a meal.
In this regard, can sulfonylureas be used with insulin?
Sulfonylurea in combination with insulin is associated with increased mortality compared with a combination of insulin and metformin in a retrospective Danish nationwide study.
Can januvia raise blood sugar?
Although by itself usually does not cause low blood sugar , low blood sugar may occur if is prescribed with other anti-diabetic medications. The recommended dose of is 100 mg once daily.
Why Is This Medication Prescribed
Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes . Sitagliptin is in a class of medications called dipeptidyl peptidase-4 inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Sitagliptin is not used to treat type 1 diabetes .
Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication, making lifestyle changes , and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage , eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
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Invokana And Januvia Drug Interactions
Invokana and Januvia drug interactions – from FDA reports Drug interactions are reported among people who take Invokana and Januvia together. This review analyzes the effectiveness and drug interactions between Invokana and Januvia. It is created by eHealthMe based on reports of 516 people who take the same drugs from FDA , and is updated regularly. On eHealthMe you can find out what patients like me reported their drugs and conditions on FDA since 1977. Our original studies have been referenced on 400+ peer-reviewed medical publications, including: The Lancet, and Mayo Clinic Proceedings. 516 people who take Invokana, Januvia are studied. Most common drug interactions over time *: Malaise Diabetic ketoacidosis is high concentrations of ketone bodies) Hallucination Diabetic ketoacidosis is high concentrations of ketone bodies) Most common drug interactions by gender *: Foetal exposure during pregnancy Dehydration Diabetic ketoacidosis is high concentrations of ketone bodies) Urticaria Hypoglycaemia * Approximation only. Some reports may have incomplete information. How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood. Want to find out more about the FDA reports used in the study? You can request them from FDA. Invokana has active ingContinue reading > >