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One Injection A Week For Diabetes Patients

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    What Is Insulin Made Of

    Insulin is made in different ways. You and your healthcare team will discuss which insulin you can take.

    • Human insulin this is synthetic and made in a laboratory to be like insulin made in the body.
    • Analogue insulin the insulin molecule is like a string of beads. Scientists have managed to alter the position of some of these beads to create genetically engineered insulin known as analogues.
    • Animal insulin This isnt used much anymore, but some people find that insulin from animals works best for them. It is usually from a cow or pig.

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    Drug Interactions Of Ozempic Vs Trulicity

    Using Ozempic or Trulicity with insulin or insulin secretagogues can increase the risk of hypoglycemia. If you take this combination of medications, your prescriber will most likely adjust the dosing of your insulin or oral medication. Also, because Ozempic or Trulicity causes delayed gastric emptying, the absorption of oral medications can potentially be affected if taken at the same time. In studies, these interactions did not occur to a clinically relevant degree however, it is a good idea to consult your healthcare provider about the timing of your medications.

    Drugs with a narrow therapeutic index should especially be monitored. These include drugs where there is a small window between therapeutic effect and toxicity such as Coumadin , Lanoxin , and seizure medications.

    This is not a full list of drug interactions. Consult your healthcare provider for a full list of drug interactions.

    Drug
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    Dulaglutide Comes As A Pen Injection

    Dulaglutide comes as a single-use pen injection, which means that each pen is used only once for one injection. The pen is ready to use. It is pre-filled with the medicine, and the needle is already fitted onto the pen. The pen is very easy to use you do not need to measure or mix anything, or see, fit or handle a needle.

    Dulaglutide pen and injection technique images courtesy of Eli Lilly and Company Limited. Reproduced with permission.

    Potential Benefits For Patients

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    Better adherence, improved quality of life

    Previous research has shown that up to 40% of patients with Type 2 diabetes decline insulin treatment, resulting in poor blood sugar control. Often, patients cite quality of life issues as to why they hesitate to use insulin:

    • Fear of needles
    • Embarrassment due to stigmas around the disease
    • Worry about fluctuating blood sugar levels

    Patients want to avoid the physical and emotional burdens of injecting insulin especially because many take several medications for other conditions, such as high blood pressure and high cholesterol.

    With a once-weekly shot, patients with Type 2 diabetes could spend less time managing their disease while still benefiting from insulin treatment.

    Improved caregiver and provider confidence

    Accurate insulin dosage is critical to the safety and well-being of patients with diabetes. Taking too much can result in hypoglycemia and cause dizziness, fatigue, shaking, heart palpitations, seizures, or unconsciousness. Taking too little would lead to high glucose levels.

    A once-weekly injection could decrease concerns regarding the accuracy of the dosage on a day-to-day basis. Fluctuating daily routines can lead to variation in dosing time of the daily insulin, which can cause low or high sugar levels. A once-weekly treatment would not be affected by such variations and would instead provide a steadier day-to-day insulin level.

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    What To Do In Case Of Overdose

    If you think youve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

    This drug comes with several warnings.

    Side Effects Of Trulicity

    Common side effects of Trulicity include stomach pain, indigestion, diarrhoea and loss of appetite. If you experience hives, difficulty breathing, or swelling, you may be allergic to Trulicity. You should seek emergency medical help immediately. If you feel any severe pain in your upper stomach, vomiting, or quickened heart rate, this could be a sign of pancreatitis Speak to your doctor about this as soon as possible.

    Other signs of serious aversion to Trulicity include swelling or a lump on your neck, low blood sugar the symptoms of which are explained here or signs of a kidney problem, such as painful urination and swelling in your feet or ankles. If you experience any of these, speak to your doctor as soon as possible.

    Rest assured that serious aversions to Trulicity are rare. They are listed here only on the off-chance that they affect you. Theres no need to worry about them unduly.

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    Who May Take Bydureon

    NICE guidance states that Bydureon is suitable for people meeting the following conditions:

    People with a BMI value below 35 may be considered for Bydureon if insulin therapy would have significant occupational implications or if the weight loss properties of Bydureon would provide significant medical benefit.

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    If You Forget Your Dose Of Dulaglutide

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    If you forget your dose, you can inject the missed dose up to 3 days later. Otherwise skip the dose and carry on as normal next week. Do not inject 2 doses at the same time.If you are unwellDulaglutide usually does not cause problems if your are slightly unwell, but if you are at risk of dehydration, with vomiting and diarrhoea and not eating and drinking as usual, you can withhold the next injection when it is due.

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    Safety And Effectiveness Of Weight Loss Drugs

    The most common side effects with semaglutide were gastrointestinal issues including nausea, vomiting, diarrhea, and constipation, which 77 to 89 percent of participants in all three study groups reported.

    Many drugs that have been approved for weight loss in the past have been withdrawn due to serious and potentially life-threating side effects, according to an editorial published in February 2021 in The New England Journal of Medicine. These include several amphetamines that caused addiction fenfluramine, which caused heart valve damage and lorcaserin, which increased the risk of cancer.

    Semaglutide is in a family of medicines known as GLP1 agonists, which mimic the action of a hormone that causes people to feel full. A similar drug, liraglutide, is already approved for weight loss in people with type 2 diabetes.

    Several other medications approved for weight loss have not achieved results as dramatic as those seen with semaglutide in the current trial, according to a review of anti-obesity treatments published in January 2021 in Current Obesity Reports. To try to isolate the effect of weight loss drugs alone, researchers subtracted the weight lost in the placebo group, which only followed lifestyle interventions, from the amount of weight lost in the study group, which followed lifestyle interventions and took medication.

    Before Taking This Medicine

    You should not use Trulicity if you are allergic to dulaglutide, or if you have:

    • multiple endocrine neoplasia type 2

    • a personal or family history of medullary thyroid carcinoma or

    • diabetic ketoacidosis .

    Tell your doctor if you have ever had:

    In animal studies, Trulicity caused thyroid tumors or thyroid cancer. It is not known whether these effects would occur in people using regular doses. Ask your doctor about your risk.

    It is not known whether dulaglutide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

    It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

    Trulicity is not approved for use by anyone younger than 18 years old.

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    What Does The Research Show About Trulicity And Weight Loss

    Studies have shown that Trulicity can lead to more weight loss than metformin alone. Its also been shown to cause more weight loss than sitagliptin , another popular diabetes medication, when added to metformin.

    The amount of weight you can lose with Trulicity may depend on the dose. In 2020, a large randomized controlled trial was conducted to see how different doses of Trulicity stacked up against each other. In the study, over 1,800 participants already taking metformin for Type 2 diabetes were started on Trulicity. All participants were started on Trulicity 0.75 mg. Their dose was raised every 4 weeks until they reached their target dose of 1.5 mg, 3 mg, or 4.5 mg.

    This study found that the degree of weight loss and improvement in blood glucose levels was dose-related. This means that people on Trulicity 4.5 mg had more weight loss than people on Trulicity 1.5 mg after about 9 months of treatment. Higher doses of Trulicity also lowered blood glucose more than lower doses.

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