Statins Help Reduce Heart Risks In People Diagnosed With Diabetes
According to Johns Hopkins Medicine, people with diabetes are two to four times more likely to develop cardiovascular disease than people without diabetes, and cardiovascular disease is the most common cause of death in people with diabetes.
Research has long shown that statins reduce heart risks among people with type 2 diabetes. For example, one study published more than a decade ago in Diabetologia examined the effect of statins on 589,091 people with type 2 diabetes. Before statin therapy, 94 percent of them had at least a 10 percent chance of experiencing an event like a heart attack or stroke in the next decade. After four months on statins, the proportion with this level of cardiovascular risk dropped by 7 percent.
People with diabetes should definitely take statins, because the benefits of statins in terms of reducing cardiovascular events far exceeds any potential risk of the statin, Dr. Newman says.
As for people without type 2 diabetes, concern about developing this condition shouldnt stop them from taking statins, either, Newman adds.
Statins increase the risk of newly diagnosed diabetes in a small percentage of patients, Newman notes. However, studies show that those patients who develop diabetes have multiple preexisting risk factors for diabetes, such as prediabetes and metabolic syndrome, and would generally develop diabetes in the long term even if they didnt take statins.
Raw Honey Helps Lower Blood Sugar And Cholesterol New Study Says
When it comes to achieving better heart health, your diet is key. Experts say whole, plant-based foods should dominate your plate, while saturated fat, salt, and sugar should be kept to a minimum.
That said, a new study suggests that not all types of sugar are created equally in the eyes of cardiometabolic impact. The researchers behind the study say that swapping your usual sugar source for raw honey could make the most of your sugar intake by helping to lower your blood sugar and improve your LDL cholesterol.
Read on for more about their fascinating findingsand to discover the one caveat they say changes everything.
Statin Takers Figured This Out Long Ago:
Q. I was put on Lipitor to control cholesterol and found it shot my blood sugar through the roof. My doctor suggested switching to Crestor. Would this drug also affect blood sugar?
A. You are not the first person to note that some cholesterol-lowering medicines might raise blood sugar levels. Another reader reported that after taking Crestor, his type 2 diabetes numbers also went through the roof. In addition, he reported: my hands, feet and arms tingled so much I could hardly stand it.
I have been taking Crestor. It lowered my cholesterol very well, but my blood sugar went out of control. My HbA1c went from 6.8 to 7.3 in just a short while, and my morning blood glucose numbers went from 110 130 to 161 217.
I stopped taking Crestor a few days ago and my numbers are already starting to drop. This morning the reading was 144 and my mid-morning blood sugar was only 96 instead of in the low 200s.
Taking A Statin Is Seldom The Answer
If your LDL cholesterol levels are HIGH, it is a sign youre in trouble. Youve got a fire brewing your metabolism is BROKEN.
Ignoring the problem, is not wisdom, but neither is jumping in and taking a statin.
You need to establish if your cholesterol levels are really high. Levels above 7.5 mM or 290 mg/dL are red flag levels, if youre somewhere in the 6s, youre fine. NOTE : Extremely low levels i.e. below 4.5 mM are not a sign of health either, theyre a red flag too, when levels are too low, your membranes dont work correctly.
Can You Control Blood Sugar And Cholesterol With Diet
Q. My doctor wants me to go back on statins even though they cause me muscle pain and cramping. I am also concerned about an increased risk for diabetes.
I take levothyroxine for hypothyroidism. Since coming off statins I have been eating more nuts, beans and whole grains. I have a salad every day with olive oil and vinegar dressing. Do you think such a regimen could help control both my blood sugar and my cholesterol?
A. Statins can raise the risk for diabetes. If not well controlled, your thyroid condition could contribute to elevated cholesterol. You may want to ask your doctor whether you are doing all you can in that regard.
An intriguing new study reveals that olive oil can lower blood lipids and inflammation and improve insulin sensitivity and blood sugar control . In addition, beans, whole grains and vinegar can help control both blood sugar and cholesterol.
To learn more about diet and other strategies to reduce your chance of developing blood sugar problems, you may want to read our eGuide to Preventing and Treating Diabetes. We also offer information on managing blood lipids, both with medications and without, in our eGuide to Cholesterol Control and Heart Health.
Other readers have also asked about the statin and diabetes connection. Here are a few examples.
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Beneficial Effects Of Statins On Diabetic Complication And/or Inflammation In T2dm
There are many factors that contribute to the development of atherosclerotic cardiovascular disease, the main mortality cause in T2DM patients. These include dyslipidemia, increased oxidative stress, enhanced protein glycation or chronic inflammatory state all of them worsen in T2DM . Statins are the gold standard treatment for the prevention and management of cardiovascular disease and their use in T2DM patients is recommended by The American Diabetes Association 2019 guidelines . In addition to the reduction of cholesterol levels and dyslipidemia improvement by reducing lipoprotein levels in plasma, the pleiotropic effects of statins reduce high sensitive C-reactive protein and other pro-inflammatory markers , improve endothelial function and reduce oxidative stress , which together contribute to a significant CVD reduction in T2DM patients.
Unfortunately, in some cases, statin treatment leads to adverse effects such as the decreased insulin sensitivity shown by atorvastatin, simvastatin and rosuvastatin . For atorvastatin and simvastatin, one proposed explanation is that the higher diffusion rate of lipophilic statins to the intracellular space can interfere with cellular processes, leading to decreased intracellular insulin secretion in response to glucose . For rosuvastatin, despite its hydrophilicity, the higher affinity and efficient transport of rosuvastatin into cells, which can underlie it effects on insulin sensitivity .
The Bottom Line On The Statin And Diabetes Connection:
Cardiologists who downplay the importance of the statin and diabetes connection confound us. People who have elevated blood sugar levels are at greater risk of heart attacks and strokes, the very things statins are supposed to prevent.
People who practice a healthy lifestyle may be able to reverse this trend. A regimen of exercise and dietary changes is capable of reversing pre-diabetes . Cut back on carbs and keep up the exercise. It can be challenging to keep this up over the long term, which is why social support is so important.
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Differences In Diabetogenic Effects Between Hydrophilic And Lipophilic Statins
As indicated in previous sections, lipophilic statins may be more diabetogenic than hydrophilic statins as they can more readily penetrate extrahepatic cell membranes such as -cells, adipocytes and skeletal muscle cells. Conversely, hydrophilic statins are more hepatocyte specific and less likely to enter -cells or adipocytes . Indeed, a high hepato-selectivity translates into minimal interference with cholesterol metabolism in tissues other than the liver and consequently to a lesser diabetogenicity . Several studies have shown that the detrimental effects of statins are dose and potency dependent and primarily related to their lipophilicity .
Do Statins Cause Diabetes
Health Canada is telling all citizens that the labels on statins have changed. All prescriptions that lower cholesterol now carry a notice warning of a raised risk of higher blood sugar content and a somewhat lesser increased risk of diabetes. The possible side effects particularly affect patients who have a pre-existing weakness for heart disease.
Health authorities everywhere have now reviewed all the available data from statin studies and concluded that the possibilities of developing diabetes is mostly among those people a propensity for the disease already. For example those people with extra high levels of glucose or triglycerides, or those people who are obese and or with hypertension. But still the overall benefits to the heart and blood systems within the body benefit more than they risk by having statins cut their cholesterol. The whole picture around statins is very complex and messages are confusing. There have been a number of health scare stories appearing in the media that receive an undue amount of attention.
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Study Uncovers Why Statins Increase Diabetes Risk And Offers Solution
Statins are drugs that lower cholesterol in the body by interfering with the production of cholesterol in the liver. Though they lower bad cholesterol and raise good cholesterol, one side effect is that they increase risk of diabetes. Now, researchers have discovered why and offer a way to suppress this side effect.
One of the worlds most widely used drugs, statins have been hailed by the medical community for their ability to prevent heart disease.
Still, the researchers, who have published their findings in the journal Diabetes, were confused as to why diabetes was linked to statin use.
Recently, an increased risk of diabetes has been added to the warning label for statin use, says lead author Jonathan Schertzer, assistant professor of Biochemistry and Biomedical Sciences, and Canadian Diabetes Association Scholar.
This was perplexing to us, he continues, because if you are improving your metabolic profile with statins you should actually be decreasing the incidence of diabetes with these drugs, yet, the opposite happened.
According to the team, around 13 million people could be prescribed a statin drug at some point in their lives.
In January of this year, the Food and Drug Administration released a Consumer Update outlining some of the risks associated with taking statins, which included an increased risk of raised blood sugar levels and the development of type 2 diabetes.
The Study Doesnt Prove A Link Between Statin Use And Diabetes Progression
One limitation of the study is the potential for diabetes progression to be detected more often among statin users simply because these patients have more frequent checkups than people who arent on statins, the study team points out.
Still, the findings offer fresh evidence of a potential risk statins pose for people with type 2 diabetes. The U.S. Food and Drug Administration in 2012 required drugmakers to add a safety warning to the labels of all statins indicating the potential of these drugs to raise blood sugar.
Overall, the risks of high cholesterol including heart attacks, strokes, and deaths from cardiovascular disease are serious enough that patients should still consider statins if their cholesterol isnt in a healthy range, regardless of the person’s heart health history, says Connie Newman, MD, an adjunct professor at the New York University Grossman School of Medicine in New York City who wasnt involved in the new study.
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Is Of Asian Descent
“I have high cholesterol. My doctor said the body processes some statins differently based on ethnic background-especially for people of Asian descent. She suggested I start taking ZYPITAMAG at the normal starting dose. So, unlike with Crestor® , I can get the full dosing range of ZYPITAMAG.”
The level of statin in your bloodstream can vary depending on several factors, one of these factors being race, which affects the way our bodies process the medications we take. In people of Asian descent, the drug metabolism pathways can sometimes lead to increased accumulation of statins.1
The new 2018 ACC/AHA Multisociety Guidelines on the Management of Blood Cholesterol recommends that extra diligence be taken with regards to statin safety in persons of Asian descent.2
Unlike Crestor® , there are no recommended dose restrictions for people of Asian descent who take ZYPITAMAG .3,4 This means that if you require a statin, you can receive the full dosing range of ZYPITAMAG.
If you are of Asian descent and have high cholesterol ask your doctor if ZYPITAMAG is right for you!
Crestor® is a trademark of the AstraZeneca group of countries1 Naito R et al. J Atheroscler Thromb. 2017 24:19-252 Grundy SM et al. J Am Coll Cardiol. 2018 Nov 10:3 Crestor® Prescribing Information. AstraZeneca Pharmaceuticals LP, Wilmington, DE August 20174 ZYPITAMAG® . Ahmedabad, India: Cadila Healthcare Ltd August 2018
Examples Of Patients On Zypitamag
These are profiles of people* who may benefit from ZYPITAMAG. Do any of these traits apply to you? If so, talk with your doctor about whether you may benefit from ZYPITAMAG too.
*Not actual patients. Individual examination is required to determine the best course of treatment. Please see important safety information and full prescribing information.
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Could Lipitor Contribute To Elevated Blood Sugar
Q. What is the relationship between long-term statin use and adult-onset type 2 diabetes? Lipitor was prescribed for me in 1998 and has successfully lowered my cholesterol.
In the past year my blood sugar went up substantially, and Ive experienced preliminary symptoms of diabetes. I have no risk factors: my weight is normal and I walk at least two miles a day with additional daily weight-bearing exercise. I have no family history of diabetes.
My diet is primarily Mediterranean because Im married to a Sicilian. Its a little high in carbs but low in red meat and high in seafood and plant proteins.
Ive stopped taking the statin. Will my metabolism return to normal?
Assessment Of Statin Use
In the DPP and DPPOS, statins use was recorded along with other concomitant medications based on self-report. This information was collected at baseline and at each semiannual follow-up visit, based on the question Has the participant taken any prescription medications within the past 2weeks? Participants were asked to bring all prescription pill bottles to each visit and drug name was recorded. Cumulative statin use was defined as the number of semiannual visits with reported use.
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Statin Therapy And Risk Of Developing T2dm: Observational Studies Clinical Trials And Meta
Statins, discovered in the early 70s and commercially available in the mid-80s, have well-characterized benefits in terms of lowering LDL-C and cardiovascular risk reduction. However, 20 years after becoming commonly prescribed, findings from observational studies showed an increased T2DM risk upon statin administration in several populations. Despite the considerable variability among these studies and the statin administered, hazard ratios were statistically significant ranging from 1.19 to 1.57, after follow-up durations of 36 years . Observational studies carried out in Canada, Taiwan and Ireland examining the association between statin administration and T2DM development, showed 1022%, 15% and 20% increases in the risk of T2DM associated with statin therapy, respectively . Later on, the effects of statin treatment on the risk of T2DM and hyperglycemia deterioration were assessed in the metabolic syndrome in men study cohort, which found that statin therapy was associated with a 46% increased risk of T2DM along with worsening of hyperglycemia . In addition, the study found statin use to be associated with a 24% reduction in insulin sensitivity and a 12% decrease in -cell count compared to individuals not taking statin therapy . Notably, treatment with both simvastatin and atorvastatin was associated with reductions in insulin sensitivity and secretion in a dose-dependent manner .