Sunday, December 4, 2022

Once Weekly Shot For Type 2 Diabetes

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Is Ozempic Or Trulicity Better

Ozempic – Uses, dose, benefits and side effects

Both drugs seem to be similar in efficacy in terms of achieving glycemic control and helping reduce weight. One study compared the two drugs and found Ozempic to be slightly better. But its important to note that the study was done by the manufacturer of Ozempic. Consult your healthcare provider to see if Ozempic or Trulicity might be an appropriate medication for you.

Are You A Good Candidate

These medications are only FDA approved for people with type 2 diabetes. They are a great choice if you are struggling with weight or if you have heart disease. If either of those apply to you, a once weekly shot may be right for you! There are a few conditions in which they are not recommended such as: history of pancreatitis, thyroid cancer or family history of thyroid cancer. Its always a good idea to discuss with your doctor about what would be best.

Coverage And Cost Comparison Of Ozempic Vs Trulicity

Both Ozempic and Trulicity are covered by most insurance and Medicare Part D plans. Check with your insurance provider for specific details/costs for your plan.

An Ozempic prescription is approximately $970. You can purchase it for $711 with a SingleCare Ozempic discount coupon.

A prescription for Trulicity can run nearly $2,000. You can save with SingleCare and pay $1,432 at participating pharmacies.

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How Do You Administer Ozempic

Ozempic is contained in a disposable plastic pen which is based on the Novonordisk flexTouch pen. The process is exactly the same as administering insulin using the flexTouch pen.

For information about the flexTouch pen visit how to use ozempic pen.

Ozempic is administered once a week as an injection under the skin.

To help remember what day to take your Ozempic , it is useful to have a reminder in your phone each week. It does not matter what day of the week to administer Ozempic so it is best to choose a day that best fits a person’s lifestyle. For example, you might choose Sunday as your day to administer Trulicity. You can place a recurring alarm in your phone, so you don’t forget. You administer it once every Sunday and that’s done. Pretty simple!

See The Inside Story : How Bydureon Bcise May Help Give You Consistent Control Of Your Blood Sugar*

Type 2 diabetes: Once

*Following 10 weeks of once-weekly dosing when the level of medicine in your bodyshould be at the optimal level.

IMPORTANT SAFETY INFORMATION

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine.

Tell your healthcare provider about all of the medicines you take, including prescription medicines and medicines for diabetes, blood pressure, pain, a water pill , warfarin, and over-the-counter medicines, vitamins, and herbal supplements, as taking them with BYDUREON BCise may affect how each medicine works.

Before using BYDUREON BCise, tell your healthcare provider if you are pregnant, nursing, or plan to become pregnant or nurse. BYDUREON BCise may harm your unborn baby.

APPROVED USES

  • Do not use BYDUREON, BYDUREON BCise, BYETTA or other medicines containing exenatide together
  • It is not known if BYDUREON BCise can be used in people with a history of pancreatitis

Please click here for Medication Guide, and click here for Full Prescribing Information for BYDUREON BCise.

You may report side effects related to AstraZeneca products by clicking here.

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What Do I Do If I Miss A Dose Of Ozempic

If you miss your dose of Ozempic , you can administer it as soon as possible within 3 days after the missed dose. After this, you can go back to your regular dosing schedule of once per week.

If there are less than 3 days until your next scheduled dose, donât take your missed dose. Take your next scheduled weekly dose and return back to your regularly scheduled weekly dose!

Potential Benefits For Patients

Better adherence, improved quality of life

Previous research has shown that up to 40% of patients with Type 2 diabetes decline insulin treatment, resulting in poor blood sugar control. Often, patients cite quality of life issues as to why they hesitate to use insulin:

  • Fear of needles
  • Embarrassment due to stigmas around the disease
  • Inconvenience
  • Worry about fluctuating blood sugar levels

Patients want to avoid the physical and emotional burdens of injecting insulin especially because many take several medications for other conditions, such as high blood pressure and high cholesterol.

With a once-weekly shot, patients with Type 2 diabetes could spend less time managing their disease while still benefiting from insulin treatment.

Improved caregiver and provider confidence

Accurate insulin dosage is critical to the safety and well-being of patients with diabetes. Taking too much can result in hypoglycemia and cause dizziness, fatigue, shaking, heart palpitations, seizures, or unconsciousness. Taking too little would lead to high glucose levels.

A once-weekly injection could decrease concerns regarding the accuracy of the dosage on a day-to-day basis. Fluctuating daily routines can lead to variation in dosing time of the daily insulin, which can cause low or high sugar levels. A once-weekly treatment would not be affected by such variations and would instead provide a steadier day-to-day insulin level.

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Common Type 2 Diabetes Injectable Drugs

There are a variety of ways to use insulin. Short-acting forms are for use just before meals. Long-acting insulin provides a base level of glucose control throughout the day. Finding the right approach for you may involve some trial and error. Here are 10 injectable drugs commonly prescribed for type 2 diabetes:

  • Albiglutide is a GLP-1 agonist. It comes as a pre-filled pen. You inject it once weekly under the skin. It does not matter when you give it as far as meals. If you want to change the day of the week you use it, you must wait at least four days from your last dose.

  • Dulaglutide is also a GLP-1 agonist for once weekly injection under the skin. It also comes in a pre-filled dosage form. Like Tanzeum, you can give it without regard to meals. You can change days of the week, but you must wait at least three days from your last dose.

  • Insulin aspart is a rapid-acting insulin you inject under the skin. It comes in two forms. One is for use 5 to 10 minutes before a meal. You can use the other 15 minutes before or after a meal. Ask your doctor or pharmacist about your dosing.

  • Insulin detemir is a long-acting insulin you inject under the skin. The usual dose is once daily with your evening meal or before bedtime. Sometimes, doctors recommend twice daily dosing.

  • Insulin glargine is another long-acting insulin. You inject it under the skin once daily at the same time every day.

  • Weekly Injection Could Aid Type 2 Diabetes Treatment

    GLP 1 Analogues: Long Acting Byetta BYDUREON- Once Weekly Treatment for Type 2 Diabetes Mellitus

    A new type of weekly injection could make type 2 diabetes treatment easier. Taking weekly injections of a medication called exenatide could help people with diabetes better manage their condition, according to recent reports. Exenatide is a type 2 diabetes drug that helps people with diabetes to control their blood glucose . Exenatide is usually prescribed to type 2 diabetics, and is not the same thing as insulin . Exenatide is marketed under the brand Byetta. A recent study conducted by experts at the Mount Sinai Hospital in the University of Toronto, Canada, and the University of North Carolina School of Medicine found that weekly injections were more effective in controlling diabetes . The study, which was published in the Lancet, was published by Amylin Pharmaceuticals and Eli Lilly .

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    Semaglutide May Boost Effects Of Diet And Exercise Changes To Increase Weight Loss

    The trial enrolled 1,210 adults with type 2 diabetes and a body mass index of 27 or higher. They all received counseling from a dietitian every four weeks, and they were all encouraged to get 150 minutes per week of exercise and to follow a diet designed to create a 500-calorie deficit each day.

    Each week, participants received injections with a placebo, a 1 mg dose of semaglutide thats already approved to treat type 2 diabetes, or a 2.4 mg dose of semaglutide that the drugs manufacturer Novo Nordisk has asked the U.S. Food and Drug Administration to approve as a weight loss aid.

    Because the weight loss achieved with placebo is assumed to stem from diet and exercise changes, as well as nutrition counseling, researchers estimated that high-dose semaglutide alone helped patients lose an average of 6.2 percent of their body weight.

    People on 2.4 mg semaglutide also had better blood sugar management by the end of the study, based on their A1C results, which show average blood sugar over around three months. At the end of the trial, participants on 2.4 mg semaglutide had average A1C readings of 6.4 percent in the prediabetes range, which is below the threshold to diagnose type 2 diabetes compared with 6.6 percent on 1 mg semaglutide and 7.8 percent on placebo.

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    Side Effects And Risks

    Ozempic and Trulicity have similar effects in the body and therefore cause very similar side effects. Below are examples of these side effects.

    Ozempic and Trulicity

    from the FDA for thyroid cancer. A boxed warning is the strongest warning the FDA requires. It alerts doctors and patients about drug effects that may be dangerous.

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    What Are The Main Differences Between Ozempic And Trulicity

    Ozempic and Trulicity are in a drug class called GLP-1 agonists, or glucagon-like peptide agonists. Both drugs are available in brand name only. The active ingredient in Ozempic is semaglutide, and the active ingredient in Trulicity is dulaglutide. However, neither drug is currently available in generic form. Both drugs are available in a pen injection form. With each weekly dose, the medication is injected subcutaneously into the abdomen, thigh, or upper arm.

    Main differences between Ozempic and Trulicity
    Ozempic
    Yes

    What Is The Best Area Of The Body To Administer Ozempic

    Byetta: A Ray of Hope for Diabetics

    The preferred site to administer the drug is the abdomen. Ozempic is only to be administered subcutaneously into the upper arm, thigh, or your abdomen. When administering into the same body region, e.g. your abdomen, choose a different injection site each week.

    Itâs important to change your injection site within the area you choose to inject, for example your thigh. It is important to change the site with each injection to reduce your risk of getting pits in your skin or thickened skin and skin with lumps.

    Here are some key points to remember when administering Ozempic:

    • Do not use the exact same spot for each Ozempic injection
    • Do not inject Ozempic where the skin has pits, is thickened, or has lumps â this can cause the Ozempic injection to not be effective
    • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin

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    Are There Side Effects To Injectable Medications I Should Be Aware Of

    Gastrointestinal side effects, such as nausea, vomiting, and diarrhea, occur in many patients. Nausea may lessen over time or by lowering the dose. It may also occur less frequently with weekly agents.

    Some reports link acute pancreatitis with GLP-1 RAs, but theres not enough data to establish a clear causal relationship. Research has explored other potential adverse effects on the pancreas, such as pancreatic cancer, but insufficient evidence exists.

    Some GLP-1 RAs may cause local skin reactions at the injection site. Some people using exenatide have reported this side effect.

    Hypoglycemia rarely occurs with GLP-1 RAs when used alone. However, adding them to insulin-based therapies can increase risk.

    In rodent studies, there was an increase in medullary thyroid tumors. A similar effect has not yet been found in humans.

    Lifestyle changes for people with type 2 diabetes may consist of:

    • modifying diet
    • losing 5 to 10 percent of body weight, for those who have overweight or obesity
    • regularly exercising for 150 minutes a week
    • self-monitoring of blood sugars
    • limiting alcohol to one drink per day for adult women and two drinks per day for adult men
    • not smoking or quitting smoking

    The diabetes plate method is commonly used for providing basic meal planning guidance and for its visual help.

    Seeing a registered dietitian may also help lead you to a healthier diet. A dietitian can recommend an individualized nutrition plan that accounts for your specific factors and preferences.

    The Next Generation Of Diabetes Therapies

    Our discovery of SMOC1, which is naturally produced by the liver and is released into the blood when glucose levels are high, could offer a new way to control blood glucose.

    We initially discovered SMOC1 as a protein that was released from mouse liver cells . Its release increased when liver cells accumulated excess fat.

    We further found SMOC1 levels in the blood to be reduced in people that are insulin resistant . Based on our animal studies and studies using human liver cells, we anticipate SMOC1 could be effective in people with type 2 diabetes, whether advanced or newly diagnosed. SMOC1 could make daily medications a thing of the past, boosting a patients quality of life.

    Given the prevalence of type 2 diabetes, this would help reduce the public health burden of the disease, with patients potentially needing fewer hospital visits and shorter hospital stays.

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    What happens next? We will need to test SMOC1 in humans, and enlist the help of the pharmaceutical industry to help develop this potential new therapy.

    With the right support, SMOC1 could move to human trials within six to eight years, helping us get closer to reducing the global public health toll of type 2 diabetes and obesity in general.

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    Do Injectables Cause Weight Loss Weight Gain

    Unlike insulin and other antidiabetic drugs, injectables dont cause weight gain.

    Because they decrease appetite, they may even contribute to weight loss in the range of 3.3 pounds to 6.6 pounds . The amount of weight loss depends on multiple factors, such as:

    • diet
    • exercise
    • use of other medications

    Because of this, GLP-1 RAs are well suited for people who are overweight or have obesity. Theyre often used in combination with other drugs or insulin to mitigate weight gain.

    GLP-1 RAs are available in prefilled pens that you administer yourself, in much the same way as insulin. They differ by dosage and duration of action.

    There are currently no comparative trials that show how choice of medication affects long-term patient outcomes.

    Your doctor will usually start you off with a low dosage. This will be gradually increased according to tolerance and desired effect.

    Fda Approves 20 Mg Dose Of Semaglutide Injection For Type 2 Diabetes

    Trulicity the Diabetes Drug Explained

    Semaglutide approved as a once-weekly subcutaneous injection for the treatment of adults with type 2 diabetes.

    The FDA has approved a 2.0 mg dose of semaglutide as a once-weekly subcutaneous injection for the treatment of adults with type 2 diabetes .

    The action expands the indicated use of semaglutide, a glucagon-like peptide-1 receptor agonist , to include 0.5, 1.0, and 2.0 mg doses for the treatment of T2D, in addition to decreased risk of major adverse cardiovascular events in adults with both T2D and cardiovascular disease.In 2017, the FDA approved semaglutide at doses of up to 1 mg subcutaneously once weekly for the treatment of TD2 mellitus.

    We are pleased with the FDA approval for a higher 2.0 mg dose of Ozempic, which further supports our purpose of driving change in diabetes care, Martin Lange, executive vice president of development at Novo Nordisk, said in a press release. The approval of the 2.0 mg dose allows more people with type 2 diabetes to achieve and maintain individualized glycemic targets and remain on the same medication for longer as their needs evolve.

    The approval for T2D was based on results from the SUSTAIN FORTE trial of 2.0 mg semaglutide injection, which found that patients treated with a higher-dose of the GLP-1 RA experienced statistically significant and superior reductions in hemoglobin A1c at week 40 compared with patients on 1.0 mg semaglutide.

    Reference

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    Warnings Of Ozempic And Trulicity

    Because both medications are in the same drug class, warnings and precautions are mostly the same. You will receive a medication guide any time you fill a prescription for Ozempic or Trulicity, which goes over side effects and warnings.

    There is a boxed warning for Ozempic and Trulicity, which is a serious warning required by the FDA. In rodents, Ozempic or Trulicity causes thyroid C-cell tumors, including MTC . It is not known whether this is caused in humans. Also, patients with a history of MTC or with multiple endocrine neoplasia syndrome type 2 should not take Ozempic or Trulicity.

    Other warnings include:

    Mounjaro Associated With Weight Loss In Clinical Trials

    Many of the participants in the Mounjaro trials also had overweight or obesity the average BMI was 32 to 34 at the time of trial enrollment. A BMI of 30 or higher is in the obesity range, according to the CDC.

    While the drug is not indicated for weight loss, average change in body weight was a secondary endpoint in all SURPASS studies, and participants lost between 12 and 25 pounds on average.

    Eli Lilly is seeking approval for tirzepatide for weight loss, and the company recently announced results from a phase 3 trial testing. Participants received the medication or a placebo over the course of 72 weeks, along with support to follow a calorie-restricted diet and to increase physical activity levels. On the highest dose participants had an average weight loss of 22.5 percent of their body weight 52 pounds.

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