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Most Common Side Effects

The most common side effects with BYDUREON BCise may include a bump at the injection site and/or nausea. Nausea is most common when you first start using BYDUREON BCise, but decreases over time in most people as their body gets used to the medicine. Other side effects that occur less often include headache, diarrhea, vomiting, injection-site itching and redness, dizziness, and constipation. Serious injection-site reactions have happened in some people who use BYDUREON. These are not all the possible side effects of BYDUREON BCise. See the below for more information and talk to your healthcare provider if you have any side effects that bother you or do not go away.

Toward A Less Burdensome Injectable

The two new trials assessed the safety and efficacy of a modified version of insulin called insulin icodec.

This has a long half-life, roughly 196 hours, making it ideal as a once-a-week treatment. Half-life refers to the time that it takes the body to metabolize and excrete half of the original dose of a medication.

Both of the studies were phase 2 trials . These can include 100300 participants with the same health-related issue who receive doses and use or undergo treatment methods shown to be safe in earlier phase 1 studies.

In both of the new trials, every participant was also taking an oral glucose-reducing medication that was not insulin, such as metformin. The studies were then randomized, which means that the participants were randomly assigned to get further doses and medications.

Both were also open-label trials , which means that the researchers and participants knew what treatments they were using.

Each study was conducted slightly differently and included varying numbers of participants with type 2 diabetes who were from different countries.

One study included 205 participants, from the U.S., Germany, Hungary, Poland, Spain, Croatia, and Slovakia, who were not currently using insulin.

The other study included 154 participants, from the U.S., Canada, Czechia, Italy, and Germany, who already use insulin. The researchers followed them for 23 weeks to assess how best to transition from daily to weekly insulin injections.

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Drug Interactions Of Ozempic Vs Trulicity

Using Ozempic or Trulicity with insulin or insulin secretagogues can increase the risk of hypoglycemia. If you take this combination of medications, your prescriber will most likely adjust the dosing of your insulin or oral medication. Also, because Ozempic or Trulicity causes delayed gastric emptying, the absorption of oral medications can potentially be affected if taken at the same time. In studies, these interactions did not occur to a clinically relevant degree however, it is a good idea to consult your healthcare provider about the timing of your medications.

Drugs with a narrow therapeutic index should especially be monitored. These include drugs where there is a small window between therapeutic effect and toxicity such as Coumadin , Lanoxin , and seizure medications.

This is not a full list of drug interactions. Consult your healthcare provider for a full list of drug interactions.

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Safety And Effectiveness Of Weight Loss Drugs

The most common side effects with semaglutide were gastrointestinal issues including nausea, vomiting, diarrhea, and constipation, which 77 to 89 percent of participants in all three study groups reported.

Many drugs that have been approved for weight loss in the past have been withdrawn due to serious and potentially life-threating side effects, according to an editorial published in February 2021 in The New England Journal of Medicine. These include several amphetamines that caused addiction fenfluramine, which caused heart valve damage and lorcaserin, which increased the risk of cancer.

Semaglutide is in a family of medicines known as GLP1 agonists, which mimic the action of a hormone that causes people to feel full. A similar drug, liraglutide, is already approved for weight loss in people with type 2 diabetes.

Several other medications approved for weight loss have not achieved results as dramatic as those seen with semaglutide in the current trial, according to a review of anti-obesity treatments published in January 2021 in Current Obesity Reports. To try to isolate the effect of weight loss drugs alone, researchers subtracted the weight lost in the placebo group, which only followed lifestyle interventions, from the amount of weight lost in the study group, which followed lifestyle interventions and took medication.

Ozempic And Other Medications

Below is a list of medications that can interact with Ozempic. This list does not contain all drugs that may interact with Ozempic.

Before taking Ozempic, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

• Drugs that increase insulin. Taking Ozempic with drugs that increase insulin levels in your body can cause hypoglycemia . Examples of these drugs include:
• insulin degludec

Ozempic helps improve blood sugar levels in people with type 2 diabetes. It does this by reducing the amount of glucose in your blood.

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What To Do In Case Of Overdose

If you think youve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

This drug comes with several warnings.

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Are You A Good Candidate

These medications are only FDA approved for people with type 2 diabetes. They are a great choice if you are struggling with weight or if you have heart disease. If either of those apply to you, a once weekly shot may be right for you! There are a few conditions in which they are not recommended such as: history of pancreatitis, thyroid cancer or family history of thyroid cancer. Its always a good idea to discuss with your doctor about what would be best.

Is Ozempic An Insulin

No, Ozempic is not an insulin. Ozempic belongs to a class of drugs called glucagon-like peptide-1 agonists. It works in people with diabetes by increasing the amount of insulin your body makes when blood sugar levels are high.

Taking too much of this medication can increase your risk of serious side effects.

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Sustained Controlled Release Is A Challenge

From a drug development point of view, one of the biggest challenges in treating diabetes is that insulin demands in the body are always changing.

In order to address this challenge, there are now treatments for type 2 diabetes that use a new class of drugs called glucagon-like peptide-1 receptor agonists. These drugs use GLP1, a signaling molecule, to trigger insulin release in the pancreas.

Because GLP1 does not last long in the body, drug developers have used various ways to extend its half-life such as fusing it with various synthetic and biological compounds. These attempts have succeeded in extending the drugs active life in the human body for up to a week.

However, the researchers note that despite this improvement, so far none of the current treatments have solved the problem of the drugs effectiveness gradually decreasing over time.

The new approach that the Duke researchers describe fuses GLP1 with a heat-sensitive biopolymer called elastin-like polypeptide. Held in a solution, the biopolymer drug can be injected into the skin with a normal needle.

Once it is in the bloodstream, the heat of the body causes the biopolymer to form a biodegradable gel that releases the drug slowly and steadily, without the peaks and troughs associated with other forms of GLP1 delivery.

Are Ozempic And Trulicity The Same

Ozempic and Trulicity are both in the drug class called GLP-1 receptor agonists. They are very similar, but not quite the same. The information above goes into more detail about each medication. Other drugs in the GLP-1 receptor agonist class include Victoza , Byetta , , and Adlyxin . There is also an oral semaglutide tablet available, with the same ingredient in Ozempic. The oral tablet is called Rybelsus.

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Expand The Important Safety Information

PURPOSE AND SAFETY SUMMARY WITH WARNINGS

Important Facts About Trulicity® . It is also known as dulaglutide.

Trulicity is a prescription medicine for adults with type 2 diabetes used to improve blood sugar and used to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in people who have heart disease or multiple cardiovascular risk factors.

• Trulicity is given through an injection . You take it once a week by injecting it under the skin of your stomach, thigh, or upper arm. Use Trulicity together with the diet and exercise that your doctor recommends.

Warnings

Trulicity may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, trouble swallowing, hoarseness, or shortness of breath. If you have a symptom, tell your doctor.

• Do not use Trulicity if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma .
• Do not use Trulicity if you have Multiple Endocrine Neoplasia syndrome type 2 .
• Do not use Trulicity if you are allergic to dulaglutide or other ingredients in Trulicity.

Ask your doctor how to recognize the serious side effects below and what to do if you think you have one:

Inflamed pancreas . Stop using Trulicity and call your healthcare provider right away if you have severe pain in your stomach area , with or without vomiting, that will not go away. You may feel the pain from your abdomen to your back.

Common side effects

What Are The Main Differences Between Ozempic And Trulicity

Ozempic and Trulicity are in a drug class called GLP-1 agonists, or glucagon-like peptide agonists. Both drugs are available in brand name only. The active ingredient in Ozempic is semaglutide, and the active ingredient in Trulicity is dulaglutide. However, neither drug is currently available in generic form. Both drugs are available in a pen injection form. With each weekly dose, the medication is injected subcutaneously into the abdomen, thigh, or upper arm.

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Before Using Ozempic Tell Your Health Care Provider If You Have Any Other Medical Conditions Including If You:

• have or have had problems with your pancreas or kidneys.
• have a history of diabetic retinopathy.
• are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if Ozempic® will harm your unborn baby or passes into your breast milk. You should stop using Ozempic® 2 months before you plan to become pregnant.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and other medicines to treat diabetes, including insulin or sulfonylureas.

Is Ozempic Or Trulicity Better

Both drugs seem to be similar in efficacy in terms of achieving glycemic control and helping reduce weight. One study compared the two drugs and found Ozempic to be slightly better. But its important to note that the study was done by the manufacturer of Ozempic. Consult your healthcare provider to see if Ozempic or Trulicity might be an appropriate medication for you.

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Trulicity : A New Glp

Diabetes, a chronic disease that is often accompanied by multiple comorbidities and health complications, is the seventh leading medical cause of death in the United States. In fact, the mortality rate for patients with diabetes is 1.5 times higher than for individuals without diabetes. Diabetes affects an estimated 29.1 million individuals in the United Statesan alarming 9.3% of the US population. In addition, an estimated 37% of US adults aged 20 years have prediabetes, according to the 20092012 National Health and Nutrition Examination Survey data. The prevalence of diabetes is projected to increase from 1 in 10 adults today to 1 in 3 adults by 2050, coinciding with the aging of the baby boom generation during the next few decades. Type 2 diabetes mellitus accounts for approximately 90% to 95% of all cases of diabetes.

Diabetes is a major cause of heart disease and stroke. In addition, diabetes is the leading cause of kidney failure, nontraumatic lower-limb amputations, and new cases of blindness in US adults. Furthermore, patients with diabetes are at an increased risk for other complications, including nerve disease, nonalcoholic fatty liver disease, periodontal disease, erectile dysfunction, hearing loss, depression, and pregnancy complications.

How Do The Dosages Of Trulicity And Ozempic Compare

The dosages of Trulicity and Ozempic vary depending on your individual treatment plan. Heres some information on the forms of each drug and standard dosages.

Like Trulicity, Ozempic comes as a liquid solution inside a disposable pen. And each medication is given as a subcutaneous injection once per week.

Trulicity comes in single-dose disposable pens. You need a new pen for each dose of Trulicity. Ozempic comes in multidose disposable pens. This means you use the same pen for more than one dose.

Trulicitys starting dosage is 0.75 mg once per week. Your doctor may increase your weekly dose to a maximum of 4.5 mg if needed.

Ozempics starting dosage is 0.25 mg once per week. Your doctor may increase your weekly dose to a maximum of 1 mg if needed.

Keep in mind that the dosages of Trulicity or Ozempic vary depending on your individual treatment plan. If you have questions about the right dosage for you, talk with your doctor.

For details on Trulicitys dosage, see What is Trulicitys dosage? above. You can learn more about Ozempics dosage here. For additional information on how Trulicity compares with Ozempic, see this article.

The dosage of Trulicity youre prescribed may depend on several factors. These include:

• the type and severity of the condition youre using Trulicity to treat
• other medications you may be taking
• any side effects you may have while using Trulicity

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