Overweight People Lost 35 To 52 Pounds On Newly Approved Diabetes Drug Study Says
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A weekly dose of a medication recently approved by the US Food and Drug Administration to treat type 2 diabetes may help adults without diabetes lose weight as well, a new study found.
Tirzepatide, which is sold under the brand name Mounjaro, was studied in people without diabetes in three dosages: 5, 10 and 15 milligrams. Participants with obesity or who were overweight and took the 5-milligram dose lost an average of 35 pounds , those on the 10-milligram dose lost an average of 49 pounds , and participants on the 15-milligram dose lost an average of 52 pounds .
Almost 40% of individuals lost a quarter of their body weight, said coauthor Dr. Ania Jastreboff, codirector of the Yale Center for Weight Management in a briefing for the media.
The data was quite impressive, said Dr. Robert Gabbay, chief medical officer of the American Diabetes Association, who spoke to CNN from the ADAs 82nd Scientific Sessions in New Orleans, where the study results were presented.
The weight loss that they got in this study was even greater than what had been seen in the previous studies of people with diabetes, Gabbay, who was not involved with the study, said.
How To Make Jeera Water For Weight Loss
The most simple and common technique of enjoying a perfect glass of this refreshing drink of jeera water in no time.
Ingredients For Jeera Water
- Gather a spoonful or two of jeera seeds
- Take 2 cups of water in a pan
Instructions To Follow
- First, you need to heat the water in a pan and toss into it a spoonful of jeera.
- Secondly, wait for some time until the water in the pan begins to boil, and allow this mixture to rest for an hour. Ensure that cumin is properly infused into the water.
- At last, switch off the flame and strain all the water. Now have a sip of your jeera water and enjoy.
Can Heart Failure Cause Emaciation
People with heart failure can emaciate. As we earlier stated, the condition, cardiac cachexia, causes such individuals to suffer adverse effects. Cardiac cachexia can cause an individual to shed muscle mass and cause inflammation that affects several organs in the body.
A person with heart disease or failure needs to contact a doctor if they have emaciation issues. This emaciation could mean that they have cardiac cachexia. Moreover, a physician will ask the person questions to confirm each symptom before concluding.
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What Happens When The Cells Absorb Too Much Glucose
When the cells absorb too much glucose, the body converts this into fat leading to weight gain . More specifically, having chronically high insulin levels translates to a condition known as hyperinsulinemia, which can lead to excessive weight gain and serious health problems like cancer and heart disease .
Moreover, high blood insulin levels can cause your cells to become resistant to the hormones effects a condition known as insulin resistance. This leads your pancreas to produce even more insulin, creating a precarious cycle .
During digestion, insulin stimulates fat, muscle, and liver cells to absorb glucose. The cells, in turn, either use this glucose for energy or convert it into fat for long-term storage. Consuming more calories than what the body needs leads to excess glucose levels. If the cells do not remove glucose from the blood, the body also contains these in the fat tissues .
While You Can Be Insulin Resistant And Not Have Any Noticeable Signs Some Common Symptoms Include:
- Weight gain or difficulty losing weight
- Blood sugar spikes after meals
- Dark patches of skin
Insulin resistance is also associated with serious health conditions, including type 2 diabetes, nonalcoholic fatty liver disease, and metabolic syndrome. So if you have several of these symptoms, talk to your doctor.
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New Weight Loss Drug Approved By Fda: Is It Right For You
More than 70% of U.S. adults are carrying extra weight, increasing their risk for chronic conditions such as type 2 diabetes, heart and liver disease, arthritis, and some cancers.
Weight loss has been shown to reduce that risk. But while the number of people trying to lose weight has risen in recent years, one national study has found that two-thirds of those who lose weight rapidly regain the weight.
Obesity is a heterogeneous disease with many different causes, and what helps one person lose weight may not work well for another person, says endocrinologist Judith Korner, MD, PhD, professor of medicine at Columbia University Vagelos College of Physicians and Surgeons and director of the Metabolic and Weight Control Center at Columbia.
Now, people who are trying to lose weight have a new optiona medication called Wegovy that is injected under the skin once a week. The medication received FDA approval earlier this summer.
In a 68-week placebo-controlled trial of nearly 2,000 participants with a body mass index of at least 27, the semaglutide group had an average weight loss of nearly 15% versus 2.4% in the placebo group. In comparison, average weight loss with other medications is 4% to 11%.
We spoke with Korner to learn more about the new drug and what people should keep in mind if they are considering the drug to help them lose weight.
How does the new drug work?
How effective is the new drug compared with other weight loss drugs and surgery?
Weight Loss Tends To Be Harder With Type 2 Diabetes
But many of these results were achieved in people without type 2 diabetes, who typically have an easier time losing weight than individuals with this metabolic disorder. In people without type 2 diabetes, a study published in February 2021 in The New England Journal of Medicine found people on semaglutide 2.4 mg lost an average of 12.4 percent of their body weight.
People with diabetes tend to lose less weight in clinical trials of anti-obesity drugs than people without obesity, says Frank Greenway, MD, medical director at the Pennington Biomedical Research Center in Baton Rouge, Louisiana.
It is not entirely clear why diabetic individuals lose less weight than nondiabetics, but one possible explanation is that people with diabetes are often told by their physicians to lose weight so they will not go blind and lose their legs, Dr. Greenway says. As a result, in an effort to help prevent these complications, people with diabetes may generally be more motivated to try to lose weight compared with people who do not have diabetes. This may mean that study participants with diabetes tend to be closer to their body weight set point than study participants without the disease at the start of clinical trials.
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Does Weight Loss Help Reduce Insulin Resistance
Weight loss does indeed decrease insulin resistance, says Hatipoglu.
A person with more fat will be more insulin resistant, she says. A person with less fat and a more lean body with more muscle will be more insulin sensitive.
A small study published in Nutrition & Diabetes analyzed the impact of weight loss maintenance and relapse on insulin sensitivity. Results showed that weight loss itself was the strongest predictor of improved insulin sensitivity, whereas weight regain significantly predicted reduced insulin sensitivity.
Why is there a connection? Hatipoglu says that fat cells play a big role in insulin resistance.
She explains that as you lose weight, fat cells get smaller, lowering levels of leptina hormone that, when too high, contributes to weight gain. At the same time, levels of adiponectina hormone that supports insulin sensitivitygo up.
Type 2 Diabetes Medications That Can Help You Lose Weight
Did you know that some of the diabetes medications you take can cause you to gain weight or lose weight? Yes, this is been scientifically proven. This weight effect is something we doctors consider when deciding which medications to prescribe to our patients. In this article, Ill give you a quick introduction to type 2 diabetes medications, and point out which are the ones that can cause weight changes.
For anyone who is living with diabetes, we are in relatively exciting times. Back about 10 15 years ago, there were only a small handful of medications for diabetes insulin, metformin, sulphonylureas. Today, we have better understanding of the various mechanisms that lead to diabetes and this has resulted in an explosion of new medications at least 10 different classes, each of them targeting a different mechanism of action and organ in our body that contributes to high blood glucose levels.
With so many options of therapy available, there is no longer an excuse for a person with diabetes not to have their glycated haemoglobin at acceptable levels.
Heres a short list of type 2 diabetes medications, in rough order of newness:
- SGLT-2 Inhibitors
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Store Ozempic In The Refrigerator Before Using
Ozempic should be stored between 36- and 46-degrees Fahrenheit in the refrigerator prior to first use. Do not freeze Ozempic pre-filled pens. After using the pen for the first time, it can be stored for 56 days at controlled room temperature or in a refrigerator. Keep the pen cap on when not in use. The pens should be protected from excessive heat and sunlight.
How Does The Condition Cause You To Lose Weight
Whenever you eat foods with carbohydrates, your body breaks them down into glucose. Your body then uses oxygen delivered through the blood to burn glucose within cells in metabolism. Metabolic processes thus produce the energy that supports bodily functions like powering your muscle cells to move and contract.
When you go to bed, however, your body does not need the energy to carry out these rigorous activities. Hence, the energy gets stored. Instead of storing the glucose directly, your body converts it to fat stored under your skin. Furthermore, the body converts the glucose to acetyl-CoA, which is easier to store and metabolize.
Patients with hyperthyroidism cannot carry out this process properly because the body automatically releases thyroid hormones into the body. These thyroid hormones promote metabolic processes even when one does not need energy. As a result, the body does not get to store any acetyl-CoA. In addition, the body converts all the stored adipose into glucose to produce energy. This process repeated for weeks or months leads to drastic weight loss. Hence, hyperthyroidism is an underlying cause of weight loss in older adults.
Please note that your bodys food breakdown is not only controlled by the thyroid hormone but also by other hormones your bodily activity, food consumption, and several other factors contribute to your overall health.
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Think About Calorie Density As You Choose Foods
When it comes to food, not all calories are the same. Some foods have a lower calorie density than othersmeaning they have fewer calories for bigger portions.
A 150-calorie serving of chips wont satisfy your hunger the way 150 calories of cucumber will at snack time. Thats because their calorie density is different. But that doesnt mean you have to stop eating chips and other foods with a high calorie density.
You just need to balance your meals out throughout the day. That means eating more foods with low caloric density to get fuller on fewer calories while also leaving room to indulge in your favorite treats with higher caloric density.
The result is a lower food intake which leads to the calorie deficit needed for weight loss.
High Insulin Levels Stop Fat Loss And Cause Weight Gain
It is impossible to have high levels of insulin in your system while burning fat at the same time. Think about that. If you eat a meal that has too high of a Glycemic Index, your blood sugar will spike, causing a large release in insulin. During this period of time your body cannot use fat for fuel . You can get everything else right and not make good progress if you allow your insulin levels to get out of whack. I Used to Think a Calorie Deficit Was Enough A while back I used to think that as long as you burned more calories than what you ingested, you would lose weight. This is true to a pointyou should lose weight under a calorie deficit. The problem lies in the fact that if you eat a high G.I. carb, you may shut down the bodys ability to burn fat for several hours. Even if you do wind up losing weight, you arent following the quickest route to your goal. A Quick Overview of Insulin You probably know what insulin is, but if you dont here is a quick summary: Insulin is a hormone that causes most of the bodys cells to take up glucose from the blood , storing it as glycogen in the liver and muscle, and stops use of fat as an energy source. When insulin is absent , glucose is not taken up by most body cells and the body begins to use fat as an energy source. Insulin and Carbs With a High Glycemic Index The Glycemic Index ranks carbohydrates according to their effect on our blood glucose levels. The rating used to go from 0 to 100sContinue reading > >
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Weight Is A Sensitive Issue For Many People And Getting To An Ideal Healthy Weight Is Easier Said Than Done But When You Have Diabetes There Are Huge Benefits To Losing Weight If You’re Carrying Extra Weight
Youll have more energy and youll reduce your risk of serious complications like heart disease and stroke. Losing weight can help with your diabetes control too. And if you have type 2 diabetes, losing weight could even mean going into diabetes remission.
But millions of people with diabetes find keeping to a healthy weight a huge struggle. You’re not alone in this, there’s support out there to help a good first step is to ask your healthcare team for help and advice.
On this page:
- Weight loss surgery.
More Support To Help You Lose Weight And Keep It Off
At no cost to you, SaxendaCare® is designed to provide the support you may need while taking Saxenda®. It can help you get the most from your treatment. When you sign up, you will have instant access to ongoing support based on scientifically proven weight-loss strategies.
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Use A Continuous Glucose Monitor
Continuous glucose monitors are small, wearable sensors used to measure the glucose in your body. They give instant feedback on which foods and lifestyle habits are best for your health goals.
In terms of weight loss, CGMs help you see exactly which foods trigger insulin and fat storage in your body in real-time, allowing you to tailor your diet with precision.
Best Foods For An Insulin Resistant Diet
Try to avoid or limit highly processed foods. Choose foods like:
- Fresh fruit like strawberries, raspberries, and blackberries
- Beans and Legumes
Carbohydrates have the biggest impact on blood sugar. Proteins have a moderate impact and fats have little to no impact on blood sugar. If you eat in a way that keeps insulin low, you will stay in a fat-burning mode. When insulin is low, your body can release fatty acids from your fat stores to use as fuel. Wouldnt you rather use your fat stores for energy?
Along with diet, there is another amazing tool you can use to help your body keep insulin levels low and use your stored fat for energy. Its called intermittent fasting.
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Eat About The Same Amount Of Food Every Day
Skipping meals may make you feel extra hungry and cause you to overeat later on. Missing meals can also lead to low blood sugar if you dont adjust your insulin dose. But eating smaller meals throughout the course of your day can help you keep your appetite, blood sugar, and weight under control.
With additional reporting by Andrea Peirce
Other Medications Can Help Reduce Insulin Needs + Help Weight Loss
If you are overweight or living with obesity, you may be eligible for other medications that can help people with diabetes lose weight.
While there are a variety of diabetes medications that support weight-loss goals and improve insulin sensitivity, there are a couple of GLP-1 agonist medications that are significantly effective in research:
These medications can help your body compensate for the thing it struggles to do: produce normal amounts of insulin. People with type 1 diabetes also dont properly produce amylina hormone that regulates appetite, blood sugar levels after eating, and liver glucose production! Its okay to need support from medications to help your body reach or manage your weight.
Educational content related to severe hypoglycemia is made possible with support from Lilly Diabetes, and editorial control rests solely on Beyond Type 1.
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Review All Medications With A Healthcare Professional
When starting a new medication, its important to review all current medications with a healthcare professional such as the prescribing doctor or a pharmacist. This includes meds that are prescriptions, over-the-counter, and supplements. With Ozempic, this is especially important as there are dose adjustments that may need to occur while using it with insulin or sulfonylureas .
Not Getting Enough Exercise
According to Cleveland Clinic, little to no exercise can make you more insulin resistant.
Remember how insulin moves glucose into your bodys cells to provide energy? Exercise builds muscle that can take in glucose from your blood.
Theres also a feedback loop. If you dont exercise, you may gain weight, which may also cause insulin resistance.
Hatipoglus advice: If you want one medication for me to give you to sensitize you to insulin, its going to be exercise.
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