Gut Microbiota In Pharmacotherapy
Metformin is a first line therapy used for T2DM implicated in the reduction in hepatic gluconeogenesis and insulin production. Beyond these effects, some studies have endorsed its potential use in loss weight, mainly due to the impact of metformin on food intake centres and as a gut microbiota regulator . More precisely, Sun et al. observed that after 3 days of metformin treatment, a significant decrease in the Bacteroides fragilis population was reported, followed by an increase in Glycoursodeoxycholic acid . This was associated with the inhibition mediated by FXR. Likewise, the positive actions of metformin in the higher production of SCFA, as well as in the growing of the bacteria Akkemansia muciniphila have been reported .
Gut Microbiota In Diabesity
Changes in gut microbiota composition have been related to a wide variety of metabolic events such as an increase in adiposity, dyslipidaemia and T2DM. These disorders bring about an increased gut permeability, disrupting bile acid metabolism, serum levels of lipopolysaccharide and affecting SCFA production and function .
To sum up, as shown in Figure 3, variations in gut microbiota composition, and its derived products are associated with an increase in adiposity, low-grade inflammation and insulin resistance, along with alterations in the endocannabinoid system, intestinal peptide production, leptin resistance and other metabolic characteristics associated with changes reported in patients with diabesity . Therefore, targeting the microbiota and its related compounds, we may understand and maximize the results of existing therapies such as lifestyle interventions, and importantly diet, bariatric surgery and even received pharmacological treatment. Furthermore, it has been reported that focusing on microbiota also makes it possible to treat mood disorders derived from diabesity . Hence, taking gut microbiota into consideration might consititute a very useful target for understanding this condition.
Type 2 Diabetes Mellitus And Its Connexion With Obesity
Obesity is often related with a wide range of complications, including cardiovascular disease, metabolic disorders like type 2 diabetes mellitus , chronic obstructive pulmonary disease, arthritis, cancer, and even psychosocial conditions . This is due to the excessive adipose tissue and fat redistribution in obese patients, which is directly implicated with hyperglycaemia, hyperlipidaemia, insulin resistance, endothelial dysfunction, and chronic inflammation . T2DM, also known as non-insulin dependent diabetes, is a condition frequently found in obese patients, and some authors consider them as a unique entity termed as diabesity . In fact it is known that up to an 85.2% of people with T2DM have a problem of being overweight or obese and by 2025, more than 300 million of people will have T2DM associated with obesity so, in the majority of cases it is not possible to understand these pathologies separately.
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Total Payments Received Between 2014 And 2018
Dr. Hutchins received less money than a majority of family physicians nationally. This overall payment amount is low, and is not necessarily a cause for concern. This graph represents paymentsDr. Hutchins received relative to the median payment received bysimilar doctors.
For more information about specific types of payments, see thebreakdown of payments by category.
The Global Challenge Of Obesity
Obesity represents one of the greatest public health concerns worldwide, being considered as an important risk factor for the development of chronic or non-communicable diseases . In addition, its economic implications also pose a serious warning for sanitary authorities . According to the last updated records from the World Health Organization , approximately 40% of people around the world are overweight, whereas 13% are obese. The prevalence of this condition has importantly increased over the years, in such a way as to almost triplicate from the 1970s, importantly affecting women . It is estimated that, in the world more people are presently overweight than underweight, and this situation is not only reported in western societies but also in developing countries, due to the lower cost of the obesogenic products . In Europe, it is expected that by 2025 up to 20% of the inhabitants could develop obesity, but a higher percentage cannot be discarded . Similarly, in Spain, recent data sustain that one in two adults are presently overweight, and around the 15% of them are obese . Childhood obesity also represents a global threat, even more worrying because of its association with an increasing morbidity and mortality from early ages . Overall, these statistics show the impact of obesity nowadays, and the necessity of deepening understanding in this important condition.
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Faqs About Dr Earl Hutchins
Is Dr. Earl Hutchins accepting new patients?
Dr. Earl Hutchins generally accepts new patients.
Does Dr. Earl Hutchins provides tele-medicine services?
Dr. Earl Hutchins has not indicated on the profile that their office offers tele-health visits. You can to find out more about telehealth visits.
Does Dr. Earl Hutchins offer same day appointments?
Dr. Earl Hutchins has not indicated on the profile that their office offers same day appointments. You can to find out more about same day appointments.
How can I make appointment with Dr. Earl Hutchins?
You can request appointment via HealthSoul or contact their office.
What are the specialties of Dr. Earl Hutchins?
The top specialties of Dr. Earl Hutchins include Family Medicine
What modes of payment are accepted by office of Dr. Earl Hutchins?
You can make payment via cash, credit card or debit card.
What is office location of Dr. Earl Hutchins?
The office is located at 22725 Hwy 76 E in Clinton, SC.
Does Dr. Earl Hutchins accepts my insurance?
Dr. Earl Hutchins accepts various types of health insurance, but individual coverage may be variable. You should check with your health insurance whether the particular doctor is in network or not.
What are the common conditions treated by family-medicine-doctor?
Last Name Possible Variations
People sometimes make mistakes in spelling last names. Below you will find a list of surnames similar to Earl Hutchins that were found in public records
|Alter Last Name|
This surname is found in public records in various versions, some of which are Hutchin, Huchins, Hutchen, Hutch, Huthins, Utchins, Hutchinsjr, Hatchins, Hutchi, Hutchines
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Clinical Strategies In Diabesity Control
Bariatric surgery may pose an interesting alternative for the clinical management of obese patients with T2DM. An open label randomized clinical trial showed the potential benefits of bariatric surgery in a five-year follow-up cohort of patients with diabesity, but it required the continuous monitoring of blood glucose levels . Nowadays, this procedure is indicated when the BMI > 35 kg/m2 and it is necessary to be incorporated into a proper context of care and permanent medical assistance . However, other studies demonstrated that this procedure may produce higher benefits in patients with a BMI 27 compared to intensive medical therapy in terms of glycaemia controlling and weight loss, reporting better results even in their quality of life , thus denoting the possibility of considering this alternative in the clinical management of diabesity. On the other hand, despite its effectivity, its high price, the possible complications associated, and the invasiveness of the procedure are other factors to be taken into account when selecting the proper therapy for each patient .
Dr Hutchins’s Medicare Feeforservice Data
Please Note: The information displayed below is sourced from the 2014 Medicare Physician and Other Supplier National Provider Identifier Aggregate Report. It’simportant to remember that the statistics below are not inclusive of all patients treated byDr. Hutchins, but only those who participate in Medicare.
- Doctor participates in Medicare?: Yes
- Number of HCPCS Codes: 56
- Number of Services: 509
- Number of HCPCS Associated With Medical Services: 46
- Number of Medical Services: 446
- Number of Medicare Patients with Medical Services: 223
Medicare Patient Demographics
- Total Number of Medicare Patients: 223
- Average Age of Medicare Patients: 71
- Number of Patients Under Age 65: 22
- Number of Patients Age 65 to 74: 120
- Number of Patients Age 75 to 84: 61
- Number of Patients Over Age 84: 20
- Number of Female Patients : 141
- Number of Male Patients: 82
- Number of Non-Hispanic White Patients: 211
- Number of Black or African American Patients: 0
- Number of Asian Pacific Islander Patients: 0
- Number of Hispanic Patients: 0
- Number of American Indian/Alaska Native Patients: 0
- Number of Patients with Race Not Elsewhere Classified: 0
- Number of Patients with Medicare Only Entitlement: 208
- Number of Patients with Medicare & Medicaid Entitlement: 15
Medicare Patient Condition Demographics
Medicare Payments Data
Medicare Prescription Drug Data
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How To Search And Find Earl R Hutchins
The population of the US is 329,484,123 people . There are at least for Earl R Hutchins in our database alone. People with the same last name and sometimes even full name can become a real headache to search for example, is found in our records 718 times.
The same person can appear under different names in public records. Quite often, people use short versions of their name , sometimes they use their names international variations . It is quite rare but still happens that a person can be found being listed under a completely different name.
The Impact Of Diet And Lifestyle Interventions In Diabesity
Diet and lifestyle interventions contribute significantly to clinical management of these conditions. The Mediterranean diet has proved to be one of the most effective choices in the clinical management of patients with diabesity and metabolic syndrome, to prevent CVDs complications PREDIMED study represents accurately the impact of this intervention in people with obesity and T2DM, markedly in the prevention of their derived complications and global mortality . In fact, thanks to interventional studies like this, it has been reported that implementing a Mediterranean diet rich in unsaturated fatty acids, is an interesting strategy with much greater efficacy than, for example, restricting the total fat intake in people with diabesity . Likewise, other studies have found some common polymorphisms such as the transcription factor TCF7L2, which may be important in precision medicine as well as a potential predictive biomarker in patients with T2DM and obesity . In addition, PREDIMED-Plus has also gained further insights into lifestyle interventions in an expanded way, including the monitoring of cognitive symptoms , quality of sleep and sleep patterns and the importance of promoting and prescript moderate and moderate-to-vigorous physical activity for an improvement in inflammatory profiles and individuals health .
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Diet And Lifestyle Interventions In Diabesity Prebiotics And Probiotics
Diet is one of the main triggers of diabesity, also being a key modulator of gut microbiota composition . For instance, the western dietary pattern, abundant in ultra-processed products, with sugar, fats, and other refined compounds and scarce in plant-based foods has been demonstrated to boost Firmicutes expansion, in particular Erysipelotrichia class, while reducing Bacillus and Bacteroidetes . The use of some additives in this diet as artificial sweeteners has been associated with an increase in Bacteroides sp. but this could derivate rapidly in an impairment in glucose tolerance, followed by a decrease in Lactobacillus reuteri . An excessive intake of saturated fatty acids was also related to diabetes progression in mice, having been related to a remarkable augmentation in bacterial translocation . Furthermore, this diet promotes a higher production of chylomicrons, which in turn leads to a significative postprandial endotoxemia, due to their role in LPS transportation .
Finally, an appropriate rest and physical activity may also promote the establishment of a healthy gut microbiota . Once again, it is important to harbour a multidisciplinary approach for the successful clinical management of such a complex disease.
Clinical Management Of Diabesity
Because of the multiple links between T2DM and obesity, numerous studies have showed that by targeting obesity, it is possible to achieve a significant improvement in T2DM. Treating obesity consists, in a simple way, of reaching weight loss in these patients. Various strategies such as lifestyle interventions, pharmacotherapy, and even major procedures like bariatric surgery have been described . Many studies have demonstrated not only how this clinical management is useful for losing weight, but also for ameliorating T2DM, notably improving their quality of life and life expectancies . It is known that concomitant therapies like antidiabetics, antidepressants or antihypertensives may have important implications in weight gain and glycaemic profiles and thus, denoting the potential effects of treating T2DM and obesity as a unique entity.
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Conclusions And Future Perspectives
Obesity is a global threat defined by the interaction of numerous factors, entailing a high economic burden since being associated with many complications, like T2DM. Evidence collected supports the importance of treating both pathologies as a unique entity, thus maximising the benefits of the therapies received by these patients. Changes in gut microbiota are a common characteristic of a wide range of diseases, among them, diabesity. Gut dysbiosis and disruption of their microbial products may be involved in this condition, although more studies are needed to possibly establish causality in this relation . In any case, it is undeniable that focusing on gut microbiota reports substantial improvements in the clinical management of diabesity, specially through diet. Moreover, it could be an important approach when considering other therapeutic options such as bariatric surgery or pharmacotherapy. Nevertheless, more lines of research are simultaneously opened, like the faecal microbiota transplant or phage therapy.
Understanding The Role Of Human Gut Microbiota
The term human microbiota refers to the totality of microorganisms inside the human body, both taking advantage of a bidirectional communication forming a single complex organism known as holobiont . It is estimated that the amount of microorganisms in a human-being is around 3.8 × 1013, being found in a 10:1 proportion with eukaryotic cells, however some authors support that this relation is close to 1:1, with a total mass between 200 g to 1 kg of the total weight of a person . On the other hand, microbiome refers to the whole microbial genome found in an individual, as well as their derived genic products, representing, approximately 100 times the human genome .
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Gut Microbiota And Bariatric Surgery
As previously outlined, bariatric surgery is a procedure which reports multiple benefits in weight loss, while improving glycaemic index in patients with diabesity. In fact, a 4080% of obese patients who undergo this surgery also recover from their T2DM . One cause explaining this outcome, is the regulatory role of bariatric surgery in gut microbiota, withits capacity to overcome gut dysbiosis having been demonstrated . Moreover, it is known that bariatric surgery directly affects the production and enterohepatic circulation of bile acids . The gut microbiota plays a key role in the biosynthesis and biotransformation of bile acids, which, in turn regulates the microbial populations through different signalling routes . One study conducted by Zhang et al. showed a significant reduction in Firmicutes and methanogenic archaea, while a rise in Gammaproteobacteria was found. Proteobacteria are stimulated by the presence of bile acids in the intestinal lumen, thus reducing the content of secondary bile acids while increasing primary bile acids . Higher serum levels of these bile acids were associated with an enhanced metabolic and hormonal profile of the patient, possibly through their effects on the Farnesoid X Receptor and G coupled protein receptor TGR5 .
Compare Dr Hutchins With Related Family Physicians
RELATED FAMILY PHYSICIAN
As a family physician, Dr. Hutchins may see patients with the following 24 conditions.Please always check with Dr. Hutchins directly about what conditions he treats, since he may treat additional conditions not listed here.
How often Dr. Hutchins performs Urinalysis relative to the2,023 other doctorsalso performing the procedure in South Carolina:
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Office Location & Contact Information
Dr. Earl practice address, contact phone number and fax are as below. Check locations where Dr. Earl practices near Greenville, SC for appointment.
- Office Address1467 Woodruff Road, Greenville, SC 29607, United States
- Organization: Bon Secours Ambulatory Services – St. Francis, Llc
Medicare AssignmentMalpractice information
Dr. Earl W Hutchins has been identified as specializing in family practice and has been in practice for more than 47 years.
Doctors can have one or more medical licenses for different specialities in South Carolina or different states. Related medical licenses for Dr. Earl W Hutchins are as mentioned below:
- Speciality: Family Medicine
- Medical Licence: 10258 – Issued in the state of South Carolina
What is Family Medicine?Family Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadth which integrates the biological, clinical, and behavioral sciences. The scope of family medicine is not…
- He attended medical school at Medical College Of Georgia and graduated in 1975.
Dr. Earl W Hutchins is professionally affiliated with the following hospitals in Greenville area and more:
- Ghs Laurens County Memorial Hospital
An affiliated hospital is a hospital where a doctor can practice and admit patients. Affiliation usually means doctors can admit patients to a hospital.
- Dr. Melissa MaxeyGeneral Surgery
Earl W Hutchins in Greenville, SC
Dr Hutchins’s Px Score
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Main Functions Of Gut Microbiota
The gut microbiota fulfils a variety of physiological functions which are crucial for host health, being an interesting subject of study from a preventive point of view . The gut microbiota is implicated in a wide range of biological processes such as digestion of some nutrients and energy balance homeostasis. This is due to the production of proper bioactive metabolites, like short chain fatty acids , which are butyrate, propionate, and acetate, considered as signalling molecules in gut and extraintestinal tissues . The synthesis of SCFAs is obtained from the colonic fermentation of the named microbiota accessible carbohydrates the non-digestible polysaccharides present in the dietetic fibre . Butyrate is principally produced by Firmicutes activity, whereas propionate and acetate are typically from Bacteroidetes .
Gut microbiota also contribute to the transport and metabolism of carbohydrates and amino acids like tryptophan, operating in the production of fat-soluble vitamins like vitamin K and water-soluble ones such as those belonging to B complex . Additionally, the gut microbiota also participates in the conversion and metabolism of bile acids, as well as the biotransformation and elimination of xenobiotics and drugs .