Monday, April 22, 2024

Pendulum Glucose Control Side Effects

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Metformin As A Type 2 Diabetes Treatment

Do Pendulum Probiotics Help Diabetes?

Metformin is a biguanide medicine. It lowers blood glucose mainly by decreasing the amount of glucose that your liver releases into the bloodstream. It also increases the sensitivity of your body’s cells to insulin. This means more glucose is taken into cells with the same amount of insulin in the bloodstream. Metformin has also been shown in studies to lower your risk of other complications of diabetes .

Metformin is almost always the first tablet advised if your blood glucose level is not controlled by lifestyle measures alone. It is particularly useful if you are overweight, as it is less likely than some other glucose-lowering tablets to cause weight gain.

Another advantage of metformin is that it generally does not cause hypoglycaemia. This is a possible problem with some other glucose-lowering tablets such as sulfonylureas, but these medicines are less often prescribed in current practice. You can also take metformin in addition to other glucose-lowering tablets if one tablet does not control blood glucose well enough on its own.Possible problems with metforminWhen metformin is first started, some people feel sick or have mildly runny stools . These are less likely to occur if you start with a low dose and gradually build up to the usual dose over a few weeks. If these side-effects do occur, they tend to ease off in time.

Other side-effects are uncommon. See the leaflet that comes in the medicine packet for full details of cautions and possible side-effects.

Nateglinide And Repaglinide As Type 2 Diabetes Treatments

Nateglinide and repaglinide have a similar action to sulfonylureas. However, they are not commonly used. After taking a dose they quickly boost the insulin level but the effect of each dose does not last very long. Each dose is taken shortly before main meals . One of these medicines may be an option if you have meals at irregular times.

Possible problems with nateglinide and repaglinideAs with sulfonylureas, possible side-effects include weight gain and hypoglycaemia. See the leaflet that comes in the medicine packet for full details of cautions and possible side-effects.

Tips For Success From The Rd

Are you looking for ways to change your lifestyle that will positively impact your type 2 diabetes diagnosis? Here are some of my tips for success.

Weight Control

Weight control is extremely important when you have type 2 diabetes. Dropping a number of pounds to bring you back to a healthy weight level cant cure you of diabetes, but it can help you better manage your glucose levels. You can also reverse many of the side effects that youve experienced from your condition. Consider a healthier diet that is approved for type 2 diabetes, combining it with a regular exercise regimen.

Healthier Diet

A plant-based diet is extremely beneficial for people who have type 2 diabetes. Fruits and veggies dont result in as dramatic of a glucose spike as a lot of other processed foods do. Work more salads, smoothies and vegetable-based soups into your diet.

Fiber

Add more fiber to your diet to slow down the absorption of sugars into the bloodstream. This keeps your blood sugar levels more controlled.

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Pendulum Therapeutics Raises $54 Million

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The Series C round nearly doubled the entirety of Pendulums previous raises, bringing the total venture capital raised to $111 million.

As lead investor, Meritech General Partner Craig Sherman will take a seat on the Pendulum Board of Directors alongside Roelof Botha, a partner at Sequoia, and Adam DAugelli, a partner at True Ventures.

We think Pendulum is a next generation pharma company doing next generation gene sequencing, said Sherman. Pendulum could be another 10x Genomics, Datadog, Snowflake or Roblox, which are Meritech investments that went public in the last two years. Pendulum feels like it could be that, because they are creating something that’s truly differentiated and could truly change a person’s life.

Craig, Roelof and I are excited about Pendulum because they are using the microbiome in an entirely new way, to create a never-before-seen product, said DAugelli. Theres a huge white space here. With many supplements, theres no way to tell if theyre even working, while medicines are synthetic and can have side effects. At Pendulum, ingredients are sourced from the microbiome that naturally lives within our bodies, and their formulas are rigorously tested for safety and effectiveness. This new hybrid product Pendulum has created is safe, requires less capital than a drug to bring to market, and could be incredibly beneficial for millions of people.

Who Can Take Glucose Control

If you have been diagnosed with type 2 diabetes and are looking for ways to better manage your condition, you could benefit from the use of Pendulum Glucose Control. This product is intended to be used under the supervision of a medical professional, so youll want to talk to your doctor before starting any kind of product regimen. Not only can you experience better control of your diabetes, but youll reap the benefits of a healthier GI system as well.

Also Check: What Kind Of Diabetes Do I Have

Medtronic Finds Children On Its Minimed 780g System Achieve Time In Range

Medtronic continues to investigate its MiniMed 780G system, which is available in 38 countries in Europe, the Middle East, and Africa and is currently being reviewed by the FDA. In October, the company announced one-year, real-world clinical data on 3,211 pediatric and adolescent patients with type 1 diabetes 15 years old and below using the MiniMed 780G system with the Guardian Sensor 3. Data on this subset of patients on the system in Europe showed an average Time in Range of 74% surpassing Clinical Consensus Guidelines and closely mirroring Time in Range for adults at 77%. Overnight Time in Range of 82% also mirrored that of adults .

From an experience perspective, younger users remained in Advanced Hybrid Closed Loop mode, also referred to as the SmartGuard algorithm, for an average of 93% of the time, similar to the 92% observed in users over 15 years old. When the pediatric group set a blood glucose target of 110mg/dL and an Active Insulin Time of two hours, they achieved an average Time in Range of 77% and a Glucose Management Indicator of 6.7%. With these settings, they only spent 2.7% of their time < 70 mg/dL .

  • 75.3% of pediatric users had a Glucose Management Indicator less than 7%, which mirrors the average A1C level that would be expected based on mean glucose.
  • 69.6% of pediatric users had a Time in Range above 70%.
  • 67.5% of pediatric users achieved both, a GMI less than 7% and a Time in Range above 70%.

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Side Effects Safety And Dosage

The manufacturers of Pendulum’s Glucose Control suggest taking 2 capsules with food one in the morning and one in the evening.

If you take Pendulums Akkermansia, youll take 1 capsule each day with food. If you choose the powdered form of the product, youll take one serving over a soft food like yogurt or applesauce and consume it immediately.

Possible side-effects related to both products may include mild gastrointestinal symptoms like nausea, loose stools, and diarrhea during the initial 35 days of use.

Glucose Control is free of all major allergens, vegan, and non-GMO. Its important to note that Glucose Control will be shipped cold and requires immediate refrigeration.

Both of Pendulums products are intended for use under medical supervision. You should speak with your physician before making any changes to your current treatment plan or daily regimen.

Summary

Pendulums Glucose Control should be taken twice a day with food, while Akkermansia should be taken once a day with food.

Both products may cause mild GI upset.

Both products are intended for use under medical supervision, and you should consult with your physician before taking the product or making any changes to your treatment plan.

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The Clinical Trial Of Pendulum Glucose Control

Pendulum Therapeutics completed the first randomized clinical trial on this product which studied the effects of four out of five of the probiotic bacterial strains included in the product. All of the human participants were previously diagnosed with type 2 diabetes and almost all participants were also taking metformin. The outcome was that these strains were well tolerated by the participants while also resulting in better glucose control.

It is important to note that these results were seen in individuals with T2D taking metformin.

How Do I Treat High Blood Sugar

Metformin Side Effects (& Consequences)

Treating high blood sugar generally depends on what has caused it. If you have regular occurrences, you should consult with your health care team to review your medicines and/or lifestyle.

You may be advised to:

  • change your diet
  • drink plenty of sugar-free fluids
  • do gentle, regular exercise
  • if you use insulin, you may be advised to adjust your dose

If your blood sugar levels are over 250-300 mg/dL, you should check your urine for ketones. Ketones appear in your urine when your body is breaking down fats for energy, and for people with diabetes, this is an indication that the management of your diabetes needs adjusting. Ketones are more common in someone with type 1 diabetes. They may be present if you have an illness, are dehydrated or have lost weight. Ketones may also appear in someone with type 2 diabetes in the case of illness.

If you have ketones in your urine you should:

  • Correct your dose of insulin and recheck your blood glucose in 1-2 hours.
  • Keep drinking water and rest do not exercise as this can increase the amount of ketones
  • See your health care team to review your treatment plan
  • If you have the following symptoms you should call your doctor as soon as possible:
  • Your blood sugar levels are not going down
  • Your breath smells fruity
  • Acetone in your urine is an extreme condition and you should go directly to the emergency room for treatment.3,4

Read Also: What Is Type Two Diabetes

Progress Report: Part 2

Endocrine research remains at the forefront of medical breakthroughs, which has led to cutting-edge treatment options, therapies, and products. Here is part 2 of Endocrine Newss closer look at some of the endocrine science innovations announced throughout 2021.

Endocrine researchers and clinicians continued to remain at the forefront of medical research, the result of which been a variety of breakthroughs that not only address new treatment options, therapies, and products, but health disparities and equity as well.

Omitting Race From Kidney Function Equations Leads To More Accurate Results

At the end of September, a paper appeared in the New England Journal of Medicine that showed omitting race from equations for estimated glomerular filtration rate leads to more accurate results when determining kidney function.

The researchers, led by Lesley Inker, MD, MS, director of the Kidney Function and Evaluation Center at Tufts Medical Center in Boston, Massachusetts, point out that the current equations that use creatinine or cystatin C incorporate age, sex, and race to estimate kidney function, but the authors write that race in these equations is a social construct and not a biological one. Inclusion of race in GFR estimating equations, along with other algorithms in medicine, is facing increasing scrutiny because race is a social and not a biologic construct its inclusion ignores diversity within and among racial groups and may contribute to systemic racism in medicine, the authors write.

For this study, the researchers developed three new eGFR equations without using race from two development data sets 10 studies for serum creatinine and 13 studies for both serum creatinine and cystatin C as well as a validation set of 12 studies. About 14% of participants in the validation set were Black, and the researchers found that the current creatinine equation that incorporates race overestimated GFR in Black patients. When the adjustment for Black race was omitted from the current eGFR equation, measured GFR in Blacks was underestimated, the authors write.

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How Pendulum Probiotics Compare To Alternatives

There is no shortage of probiotics on the market to choose from, but there is a shortage of evidence-based products intended to help manage blood sugar control.

While the strains in Pendulum products may help people with type 2 diabetes improve their blood sugar control, other less expensive strains may help as well.

Bio-Kult Advanced Probiotics

According to one 2017 review, the probiotic strains Lactobacillus and Bifidobacterium may help improve H1C levels, lower fasting blood sugar levels, and improve insulin resistance.

Bio-Kult Advanced Probiotics provide Lactobacillus acidophilus, Bifidobacterium longum, Bacillus subtilis, and 11 more strains to promote a healthy gut microbiome.

The product doesnt require refrigeration, is third-party tested, and is significantly less expensive than the probiotics offered by Pendulum. A 1-month supply of Bio-Kult Advanced Probiotics can be purchased through Amazon for $27.

It is important to note that while Bio-Kult Advanced Probiotics does provide Lactobacillus and Bifidobacterium, both of which may help manage blood sugar control, the product has not been clinically tested to help manage blood sugar control the way that Pendulums products have.

Klaire Labs Ther-Biotic Complete

One 2016 review found that people with type 2 diabetes who took probiotics for at least two months had a 16-mg/dl decrease in fasting blood sugar and a 0.53% decrease in A1C compared to those taking a placebo.

Summary

Does The Pendulum Probiotic Work For Type

The wonderful thing about Pendulum Glucose Control is that it uses scientific information to provide the most optimal type 2 diabetes support available. There are a few different aspects to this condition and addressing each of them is what makes this product effective. For example, using these proven strains of probiotics to balance your gut and create a more diverse microbiome can result in better management of your type 2 diabetes symptoms while also reducing your risk of long-term effects.

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Company Created New Product Category Filling Market Gap Between Supplements And Prescription Drugs

Pendulum Therapeutics a biotech company improving health through products targeting the microbiome today announced a $54 million investment led by Meritech Capital with participation from existing investors including Sequoia Capital, True Ventures and Khosla Ventures. This Series C round nearly doubled the entirety of Pendulums previous raises and brings the total venture capital raised to $111 million.

As lead investor, Meritech General Partner Craig Sherman will take a seat on the Pendulum Board of Directors alongside Roelof Botha, a partner at Sequoia, and Adam DAugelli, a partner at True Ventures.

We think Pendulum is a next generation pharma company doing next generation gene sequencing,

said Sherman.

Pendulum introduced its first product, a medical probiotic called Pendulum Glucose Control, in January 2020. It is the only probiotic clinically shown to lower blood sugar spikes and A1C levels in people with type 2 diabetes, even on top of metformin. Results of Pendulums gold standard clinical trial were in BMJ Open Diabetes, a prestigious peer-reviewed journal.

Pendulum Glucose Control is welcome news for more than 120 million people living with diabetes and prediabetes. The company reported a surge in demand in Q4 2020 and Q1 2021, and high customer satisfaction across several measures*:

said Colleen Cutcliffe, PhD, cofounder and CEO of Pendulum Therapeutics.

About Pendulum Therapeutics

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Is One Medication Better Than Another For Type 2 Diabetes Treatment

According to international guidelines, patients should take metformin as their first-line type 2 diabetes treatment unless there is a medical reason that it should not be prescribed.

However, in recent years, many new medicines have been developed for type 2 diabetes treatment. It has now been shown that some of them offer benefits in addition to glucose-lowering. For instance, SGLT-2 inhibitors in particular may protect the heart and kidneys. Therefore, they may be offered in addition to metformin as first-line treatment for people with certain health conditions or risk factors. You can find out more about who might be offered them under the section below on SGLT-2 inhibitors.

For other people with type 2 diabetes, various factors should be taken into account when choosing a ‘second-line’ medication to add to metformin. You can find out more about the individual medicines later in this leaflet.

Read Also: Type 2 Diabetes Support Groups Online

Pendulum Therapeutics Secures Funding To Help Meet Consumer Demand

The new venture capital funding will be used to increase the manufacturing and sales of Pendulum Glucose Control, ramp up the manufacturing of pipeline products to address the management of other chronic diseases, and conduct additional research, including clinical trials.

Pendulum Therapeutics announced a $54 million investment led by Meritech Capital with participation from existing investors including Sequoia Capital, True Ventures and Khosla Ventures, to help meeting surging consumer demand. The Series C round nearly doubles the entirety of what Pendulum has previously raised in total venture capital to $111 million. The new venture capital funding will be used to increase the manufacturing and sales of Pendulum Glucose Control, ramp up the manufacturing of pipeline products to address the management of other chronic diseases, and conduct additional research, including clinical trials.

We think Pendulum is a next generation pharma company doing next generation gene sequencing, said Craig Sherman Meritech general partner, in a press release. Pendulum could be another 10x Genomics, Datadog, Snowflake or Roblox, which are Meritech investments that went public in the last two years. Pendulum feels like it could be that, because they are creating something that’s truly differentiated and could truly change a person’s life.

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How Important Is Glucose Control With Type 2 Diabetes

Metformin Side effects | Tips to Avoid

Managing your glucose levels when you have type 2 diabetes is incredibly important. This is essentially how you can prevent complications from occurring. Glycemic control is what your doctor will talk to you about once youve been diagnosed. This involves watching the foods that you eat and how they affect your body. You want to avoid having too much glucose in your bloodstream at any point in time.

When you dont properly maintain your condition, you could develop an immediate reaction where abnormally high levels of glucose are in the blood. This is a medical emergency that can cause death. Atherosclerosis , damage to your eyes, nerve damage, kidney failure, stroke and amputation are all type 2 diabetes complications that can develop if youre not controlling your glucose.

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