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Most Effective Type 2 Diabetes Medications

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Farxiga Can Help With Your First Prioritylowering Your A1c

FARXIGA is a once-daily pill proven to help lower A1C, along with diet and exercise.

FARXIGA + METFORMIN XR helps lower A1C by this number of points when used as the first drug therapy for type 2 diabetes.*

*Average reduction with 5mg + metformin XR when starting at 9.2% A1C. Metformin XR alone lowered A1C by 1.4% when starting at 9.1% A1C. Individual results may vary.

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Most Diabetes Medications Effectively Lower Blood Sugar

The blood sugar goal for most adults with diabetes is an A1C of below 7%. In many people, diet and exercise are not enough to reach this goal, and one or more medications may be needed. Metformin is a tried and tested medicine that has been used for many decades to treat type 2 diabetes, and is recommended by most experts as first-line therapy. It is affordable, safe, effective, and well tolerated by most people.

When metformin does not adequately control blood sugar, another medication must be added. It is at this point that doctors and patients must choose among the many drugs and drugs classes available to treat type 2 diabetes. In general, for people who are at low risk of heart disease or have no history of diabetic kidney disease, most diabetes medications that are added to metformin effectively reduce blood sugars and can lower A1C to under 7%.

So, how to choose a medication? Each person with diabetes has their own goals, needs, and preferences. Before choosing a medicine, it is important to ask some relevant questions: Is my blood sugar at goal? Is this medicine affordable? Do I have heart or kidney disease? What are the side effects? Is it a pill or injection, and how often is it taken?

Regardless of which treatment is selected, the American Diabetes Association Standards of Care recommends reassessment of diabetes control every three to six months, followed by modifications to treatment if needed.

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How To Lower Blood Sugar Without Insulin Quickly

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What Is The Most Common Oral Medication For Type 2 Diabetes

Metformin is the most common oral medication for Type 2 diabetes. Its been around a long time and is very well studied. Because of this, healthcare providers often recommend trying metformin first.

Providers also prescribe metformin as the first choice for gestational diabetes if medication is necessary.

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Can I Overdose On Oral Diabetes Medications

Is diet and exercise effective for type 2 diabetes treatment?

Always take your medications as prescribed by your healthcare provider. Read the directions carefully and follow them. If youre unsure how much youre supposed to take, call your provider.

One particular risk of taking certain oral diabetes medications is low blood sugar .

As oral diabetes medications work by lowering your blood sugar levels, if your dose is too high or you take more than whats prescribed, you could experience hypoglycemia blood sugar thats lower than 70 mg/dL. This risk is especially increased with meglitinides and sulfonylureas.

Without proper treatment, severe hypoglycemia can be life-threatening. Hypoglycemia symptoms include:

  • Shaking or trembling.

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Implications For Diabetes Treatment

While I dont think that any of the findings from this study were particularly surprising, this study allows providers to see head-to-head comparisons of the different agents for the first time. It confirmed the many known pros and cons of the medications, said Dr. Ferris.

Further, suggests that liraglutide, which has been shown to be beneficial for cardiovascular risk in a high-risk population, likely provides benefit to a lower risk group of people with diabetes, she added.

This study was designed to provide providers with important information on how to guide the long-term management of type 2 diabetes, said Dr. Henry Burch , Program Director at the National Institute of Diabetes and Digestive and Kidney Diseases , one of the studys authors.

This is an integral step toward precision medicine for diabetes care, as these results can now be used in the decision-making process for each individual patient in light of their levels of glucose control, how well the medications are tolerated, and the persons other health considerations, Dr. Burch added.

The researchers concluded that glargine and liraglutide, when added to metformin, are modestly more effective than other drugs at achieving and maintaining average blood glucose levels in the target range.

How Eastern And Western Medicine Tackles Diabetes

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How To Know Your Diabetes Is Under Control

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What Medicines Cause Type 2 Diabetes

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What Are Some Once Weekly Medications For Diabetes Control

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Newer Diabetes Medications: Weighing Benefits And Risks

Lately, newer treatment options for type 2 diabetes glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors have been heavily advertised. These newer drug classes lower blood sugar and also have cardiovascular and kidney benefits.

GLP-1 receptor agonists are drugs that lower blood sugar after eating by helping your bodys insulin work more efficiently. All drugs in this group except one are self-injected under the skin, either daily or weekly. Several of them, such as liraglutide , semaglutide , and dulaglutide , have been shown to lower the risk of cardiovascular disease in people who are at high risk for it, or who have pre-existing heart disease. They also promote weight loss. Some people who take GLP-1 receptor agonists may have side effects such as nausea and vomiting, and in very rare cases pancreatitis.

While these diabetes medications certainly have more to offer than just improvements in blood sugar, they remain costly and inaccessible to many individuals. This is why it is essential to have an open and honest conversation with your doctor about what is most important to you and what aligns with your goals and preferences. Management of a complex disease like diabetes takes an entire team, with you being the key team member.

About the Author

Samar Hafida, MD, Contributor

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How Do Oral Diabetes Medications Work

All oral diabetes medications share one goal: To help lower blood glucose levels to a healthy range.

A significant contributor to the development of Type 2 diabetes is insulin resistance.

Insulin resistance, also known as impaired insulin sensitivity, happens when cells in your muscles, fat and liver dont respond as they should to insulin. Insulin is a hormone your pancreas makes. It allows your body to turn the glucose you consume from food into energy. This is an essential, life-sustaining process.

As a result of insulin resistance, your pancreas has to release more insulin to try to keep your blood sugar levels in a healthy range. If your pancreas cant release enough insulin, your blood sugar levels rise, causing hyperglycemia . Long-term hyperglycemia can cause several health issues.

Insulin resistance is a complex phenomenon. Oral diabetes medications work in different ways to lower blood sugar, including helping your pancreas produce more insulin. Beyond medication, exercise is a key part of naturally reducing insulin resistance.

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